Nakagawa H, Min K R, Nanjo K, Tsurufuji S
Jpn J Pharmacol. 1979 Aug;29(4):509-14. doi: 10.1254/jjp.29.509.
Effect of progesterone (1 mg/kg) on the inflammation in rats induced by carrageenin was studied. Progesterone inhibited the vascular permeability and the formation of granulation tissue in the early phase of the inflammation. In the chronic proliferative phase, progesterone suppressed the vascular permeability and there was an active resorption of the granulation tissue. Increased degradation of noncollagen protein was observed in the treated group without apparent influence on the metabolism of collagen or on the synthesis of noncollagen protein. The mode of action of progesterone was compared with that of a potent anti-inflammatory steroid, hydrocortisone acetate.
研究了孕酮（1毫克/千克）对角叉菜胶诱导的大鼠炎症的影响。孕酮在炎症早期抑制血管通透性和肉芽组织形成。在慢性增殖期，孕酮抑制血管通透性，肉芽组织有活跃的吸收。在治疗组中观察到非胶原蛋白降解增加，对胶原蛋白代谢或非胶原蛋白合成无明显影响。将孕酮的作用方式与强效抗炎类固醇醋酸氢化可的松的作用方式进行了比较。
