锂神经毒性。
Lithium neurotoxicity.
作者信息
Newman P K, Saunders M
出版信息
Postgrad Med J. 1979 Oct;55(648):701-3. doi: 10.1136/pgmj.55.648.701.
Abstract
The peripheral and central neurotoxic effects of lithium carbonate are illustrated by 4 case histories. Lithium neurotoxicity is likely to be more common than the literature suggests. Neurological sequelae may be irreversible and may be associated with therapeutic serum levels. Prevention may be facilitated by more stringent case selection, EEG and clinical monitoring and the development of improved methods of drug level assessment.
摘要
4例病史说明了碳酸锂的外周和中枢神经毒性作用。锂神经毒性可能比文献报道的更为常见。神经后遗症可能是不可逆的，且可能与治疗性血清水平相关。更严格的病例选择、脑电图和临床监测以及改进药物水平评估方法可能有助于预防。
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本文引用的文献
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Lithium salts in the treatment of psychotic excitement.锂盐治疗精神病性兴奋。
Med J Aust. 1949 Sep 3;2(10):349-52. doi: 10.1080/j.1440-1614.1999.06241.x.
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Neurological sequelae after lithium intoxication.锂中毒后的神经后遗症。
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Emergence of myasthenia gravis during treatment with lithium carbonate.碳酸锂治疗期间重症肌无力的出现。
Arch Gen Psychiatry. 1976 Sep;33(9):1090-2. doi: 10.1001/archpsyc.1976.01770090080007.
4
Lithium in the treatment of a manic patient with multiple sclerosis: a case report.锂盐治疗一名患有多发性硬化症的躁狂患者：病例报告
Dis Nerv Syst. 1977 Mar;38(3):210-1.
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Severe neurotoxicity despite "therapeutic" serum lithium levels.
Dis Nerv Syst. 1977 Feb;38(2):107-11.
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