Aimard G, Boisson D, Trouillas P, Devic M
Rev Neurol (Paris). 1979 Nov;135(10):679-92.
A retrospective study was conducted on sixteen cases of encephalitis or acute amnesic encephalopathies, only one of which was confirmed by pathological examination, seen over the last fifteen years. The amnesic syndrome was always associated with a very marked anterograde deficiency and the absence of severe disturbances of other higher functions. Its onset was always acute, was secondary to disturbances of consciousness or associated with epilepsy, and in half of the cases presented as a severe infections disorder with high fever. The mood and behavioural disorders, and the temporal epilepsy, were evidenced clinically as a pure or predominant hippocampic lesion. The diversity of the progressive nature of the disorders, and the etiological environmental factors, enable divison into three groups : a group of six cases of postencephalitic Korsakoff's syndrome, probably of herpetic origin, and associated with a stable amnesic syndrome which remained as a sequela ; a group of 5 patients with non-herpetic but probable viral "curable amnesic encephalitis" ; another group of 5 patients with "acute amnesic encephalopathy" with various etiologies and with obvious encephalitic lesions.
对过去15年中所见的16例脑炎或急性遗忘性脑病进行了回顾性研究，其中仅1例经病理检查确诊。遗忘综合征总是伴有非常明显的顺行性缺陷，且无其他高级功能的严重障碍。其起病总是急性的，继发于意识障碍或与癫痫相关，半数病例表现为伴有高热的严重感染性疾病。情绪和行为障碍以及颞叶癫痫在临床上表现为单纯或主要的海马病变。疾病进展性质的多样性以及病因环境因素，使得可分为三组：一组6例脑炎后柯萨科夫综合征，可能源于疱疹，伴有稳定的遗忘综合征并遗留后遗症；一组5例非疱疹性但可能为病毒性的“可治愈性遗忘性脑炎”患者；另一组5例病因各异且有明显脑炎病变的“急性遗忘性脑病”患者。
