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抗淋巴细胞血清治疗多发性硬化症:对50例患者进行4年随访的初步研究结果(作者译)

[Treatment of multiple sclerosis with antilymphocyte serum: results of a pilot study on 50 patients followed-up over a 4-year period (author's transl)].

作者信息

Lhermitte F, Marteau R, De Saxce H

出版信息

Rev Neurol (Paris). 1979 Jun;135(5):389-400.

PMID:538387
Abstract

Intensive antilymphocyte serum treatment was given to 50 patients with severe, progressive multiple sclerosis for a period of 6 weeks. Conclusions were favourable as regards the possibility of using this treatment and its immunodepressive effect. Therapeutic efficacy is difficult to evaluate, but a favourable impression was obtained from the fact there was improvement and transitory stabilization in some of the patients. These results suggest that the study should be continued, using longer treatment, on more recent cases, and with a randomized control group.

摘要

对50例重度、进展性多发性硬化症患者进行了为期6周的强化抗淋巴细胞血清治疗。关于使用这种治疗方法的可能性及其免疫抑制作用,结论是有利的。治疗效果难以评估,但从一些患者病情有所改善和短暂稳定这一事实中获得了良好的印象。这些结果表明,该研究应继续进行,采用更长时间的治疗,针对更新的病例,并设立随机对照组。

相似文献

1
[Treatment of multiple sclerosis with antilymphocyte serum: results of a pilot study on 50 patients followed-up over a 4-year period (author's transl)].抗淋巴细胞血清治疗多发性硬化症:对50例患者进行4年随访的初步研究结果(作者译)
Rev Neurol (Paris). 1979 Jun;135(5):389-400.
2
[Treatment of progressive and severe forms of multiple sclerosis using a combination of antilymphocyte serum, azathioprine and prednisone. Clinical and biological results. Comparison with a control group treated with azathioprine and prednisone only. 4-year follow-up].[使用抗淋巴细胞血清、硫唑嘌呤和泼尼松联合治疗进展型和重症多发性硬化症。临床和生物学结果。与仅用硫唑嘌呤和泼尼松治疗的对照组比较。4年随访]
Rev Neurol (Paris). 1987;143(2):98-107.
3
[Immunosuppressive treatment of multiple sclerosis. 4. Results of treatment with azathioprine and antilymphocyte globulin (author's transl)].
MMW Munch Med Wochenschr. 1977 Sep 2;119(35):1111-4.
4
[Antilymphocyte globulin in intensive immunosuppression in patients with multiple sclerosis].
Postepy Hig Med Dosw. 1978 Jul-Aug;32(4):513-22.
5
Pilot study with antilymphocyte globulin in the treatment of multiple sclerosis.
Postgrad Med J. 1976;52(5 Suppl):123-30.
6
[The problem and value of therapy in multiple sclerosis].[多发性硬化症治疗中的问题与价值]
Psychiatr Neurol Med Psychol (Leipz). 1988 Oct;40(10):598-608.
7
[Immunosuppressive treatment of multiple sclerosis. 3. Results of treatment with azathioprine and antilymphocytic globulin (author's transl)].
MMW Munch Med Wochenschr. 1974 Nov 29;116(48):2105-12.
8
[Immunosuppressive treatment im multiple sclerosis].[多发性硬化症的免疫抑制治疗]
Fortschr Med. 1980 Oct 2;98(37):1431-6.
9
Toleracne to equine IgG after immunosuppression in patients with multiple sclerosis.
Postgrad Med J. 1976;52(5 Suppl):136-8.
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Antilymphocyte globulin and adrenal steroids in the treatment of multiple sclerosis: short report based on seven cases.抗淋巴细胞球蛋白与肾上腺皮质类固醇治疗多发性硬化症:基于7例的简短报告
Boll Ist Sieroter Milan. 1979 Sep 30;58(4):339-43.