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抗淋巴细胞血清治疗多发性硬化症:对50例患者进行4年随访的初步研究结果(作者译)

[Treatment of multiple sclerosis with antilymphocyte serum: results of a pilot study on 50 patients followed-up over a 4-year period (author's transl)].

作者信息

Lhermitte F, Marteau R, De Saxce H

出版信息

Rev Neurol (Paris). 1979 Jun;135(5):389-400.

PMID:538387
Abstract

Intensive antilymphocyte serum treatment was given to 50 patients with severe, progressive multiple sclerosis for a period of 6 weeks. Conclusions were favourable as regards the possibility of using this treatment and its immunodepressive effect. Therapeutic efficacy is difficult to evaluate, but a favourable impression was obtained from the fact there was improvement and transitory stabilization in some of the patients. These results suggest that the study should be continued, using longer treatment, on more recent cases, and with a randomized control group.

摘要

对50例重度、进展性多发性硬化症患者进行了为期6周的强化抗淋巴细胞血清治疗。关于使用这种治疗方法的可能性及其免疫抑制作用,结论是有利的。治疗效果难以评估,但从一些患者病情有所改善和短暂稳定这一事实中获得了良好的印象。这些结果表明,该研究应继续进行,采用更长时间的治疗,针对更新的病例,并设立随机对照组。

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