吗啡依赖对大鼠胰腺小动脉平滑肌中肾上腺素能神经囊泡含量的影响。
The effect of morpine dependence on the vesicular content of adrenergic nerves in relation to arteriolar smooth muscle in the pancreas of the rat.
作者信息
Graham J D, Lever J D, Spriggs T L
出版信息
Br J Pharmacol. 1969 Sep;37(1):19-23. doi: 10.1111/j.1476-5381.1969.tb09517.x.
Abstract
- Sibling male Wistar rats were kept in groups of three under identical conditions. Two groups were made morphine dependent in 28 days and the third served as control. The state of dependence was established by recording the development of tolerance to the analgesic action of the drug and the effect of acute withdrawal of morphine and injection of nalorphine on one test group.2. Animals in the other test group and the control group were killed and specimens of pancreas collected and prepared for examination by electron microscopy. The adrenergic innervation of pancreatic arterioles was located and photographed and the effect of morphinization on the percentage of granular and agranular small vesicles in the axons determined.3. Morphinization produces a significant reduction in the granular or dense core vesicle population of these adrenergic axons.
摘要
同窝雄性Wistar大鼠以三只一组的形式饲养在相同条件下。两组在28天内形成吗啡依赖，第三组作为对照组。通过记录对药物镇痛作用耐受性的发展以及在一个试验组中吗啡急性戒断和注射烯丙吗啡的效果来确定依赖状态。
另一个试验组和对照组的动物被处死，收集胰腺标本并制备用于电子显微镜检查。定位并拍摄胰腺小动脉的肾上腺素能神经支配，确定吗啡化对轴突中颗粒状和无颗粒小泡百分比的影响。
吗啡化使这些肾上腺素能轴突的颗粒状或致密核心小泡数量显著减少。
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The effect of morpine dependence on the vesicular content of adrenergic nerves in relation to arteriolar smooth muscle in the pancreas of the rat.吗啡依赖对大鼠胰腺小动脉平滑肌中肾上腺素能神经囊泡含量的影响。
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