对牛-吉氏盘尾丝虫、喉瘤盘尾丝虫模型作为人体抗盘尾丝虫病药物三级筛选模型的评估。
An evaluation of the bovine -- Onchocerca gibsoni, Onchocerca gutturosa model as a tertiary screen for drugs against Onchocerca volvulus in man.
作者信息
Coperman D B
出版信息
Tropenmed Parasitol. 1979 Dec;30(4):469-74.
In this trial suramin, diethylcarbamazine, trichlorphon, levamisole, mebendazole, melarsonyl potassiu, Hoechst 33258 and tinidazole were administered to cattle infected with O. gibsoni and O. gutturosa to determine the usefulness of this screen in predicting the effect of drugs in man against. O. volvulus except for melarsonyl potassium which was macrofilarticidal against O. gutturosa but not O. gibsoni when cattle were slaughtered 6 weeks after treatment. It was concluded that cattle infected with O. gibsoni are a satisfactory substitute for chimpanzees infected with O. volvulus, as a tertiary screen for drugs against O. volvulus, but that their use would be restricted to centres in O. gibsoni endemic areas where the necessary facilities and specialised knowledge required to use cattle as experimental animals exist.
在该试验中，给感染了吉氏丝状线虫和喉瘤丝状线虫的牛施用了苏拉明、乙胺嗪、敌百虫、左旋咪唑、甲苯达唑、美拉胂钾、赫斯特33258和替硝唑，以确定此筛选方法在预测药物对人体抗旋盘尾丝虫效果方面的有效性。除美拉胂钾外，其他药物在治疗6周后屠宰牛时，对吉氏丝状线虫无效，但对喉瘤丝状线虫有杀成虫作用。得出的结论是，感染吉氏丝状线虫的牛可作为感染旋盘尾丝虫的黑猩猩的满意替代物，作为抗旋盘尾丝虫药物的三级筛选模型，但它们的使用将限于吉氏丝状线虫流行地区有必要设施和使用牛作为实验动物所需专业知识的中心。
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