Finn H, Bienia M
Z Gesamte Inn Med. 1979 Jul 1;34(13):357-62.
By means of hepatological examinations of 119 blood donors who became conspicuous by liver screenings in 57 cases we could prove an adipose degeneration without, in 16 cases a fatty degeneration of the liver without, in 9 cases an adipose degeneration with and in 15 cases a fatty degeneration of the liver with mesenchymal reaction. Only 9 blood donors had normal liver findings. 90% of the punctured blood donors had an overweight up to a maximum of 35 kg in comparison to the ideal weight. 30% of the punctured patients admitted a clearly increased daily consumption of alcoholic beverages. By means of repeated punctures on 24 blood donors after 8 to 32 months after an adequate consultation in three cases a normalisation and in eight cases an improvement of the liver findings could be proved. In 13 cases the findings remained unchanged, also the anamnestic and clinical findings corresponded to this. In 2 blood donors by means of a threefold liver puncture in the observation period of 48 months also a clear retrogression of the liver findings was proved. With this was also connected the reduction of overweight and the avoiding of alcohol. Thus our investigations confirmed that overweight and abuse of alcohol are essential factors for the development of a fatty degeneration of the liver. Of an infectious hepatitis reported in the anamnesis in 10 blood donors histologically in no case residues were established. Thus the liver dispensary is of great importance for the care of blood donors who become conspicuous by screening tests. On the one hand the importance is referred to the blood donor himself, on the other hand to the group of donors. Blood donors taken out of the group could again be included in the special group, when after the exclusion of known noxae the retrogression of unspecific liver changes took place.
通过对119名在肝脏筛查中表现异常的献血者进行肝脏检查,我们证实其中57例存在脂肪变性,16例存在无间质反应的肝脏脂肪变性,9例存在有间质反应的脂肪变性,15例存在有间质反应的肝脏脂肪变性。只有9名献血者肝脏检查结果正常。与理想体重相比,90%接受穿刺检查的献血者超重,最多超重35千克。30%接受穿刺检查的患者承认日常酒精饮料摄入量明显增加。在对24名献血者进行充分咨询后,8至32个月内再次穿刺,结果显示3例肝脏检查结果恢复正常,8例有所改善。13例结果未变,既往史和临床检查结果也与之相符。在2名献血者中,经过48个月的观察期内三次肝脏穿刺,也证实肝脏检查结果明显好转。这也与超重减轻和戒酒有关。因此,我们的研究证实超重和酗酒是肝脏脂肪变性发展的重要因素。在10名献血者的既往史中报告有传染性肝炎,但组织学检查未发现任何残留病变。因此,肝脏诊疗所对于护理在筛查中表现异常的献血者非常重要。一方面对献血者本人很重要,另一方面对献血者群体也很重要。当排除已知有害因素后非特异性肝脏改变消退时,从献血者群体中剔除的献血者可再次被纳入特殊群体。