Grunnet N, Kristensen T, Kissmeyer-Nielsen F
Tissue Antigens. 1975 Oct;6(4):205-20. doi: 10.1111/j.1399-0039.1975.tb00635.x.
In general it can be said that the HL-A (LA and FOUR) antigens seem to be of major qualitative and partly quantitative importance for the degree of destruction in Cell Mediated Lympholysis (CML). This has been established by analyses of 1299 effector/target combinations involving 97 different healthy individuals. The main observation is that the cytolytic capacity of MLC effectors is positively ranked with the number of HL-A (LA and FOUR) antigens introduced by the incompatibility between stimulator, effector and target lymphocytes. However, the fact that not all cytolytic situations can be explained by the HL-A system stresses that other specific antigens (Target Determinants) may interfere with the Cell Mediated Lympholysis.
一般来说，可以说HL - A（LA和FOUR）抗原对于细胞介导的淋巴细胞溶解（CML）中的破坏程度似乎在质量上具有主要重要性，并且在一定程度上在数量上也具有重要性。这是通过对涉及97名不同健康个体的1299种效应细胞/靶细胞组合进行分析而确定的。主要观察结果是，混合淋巴细胞培养（MLC）效应细胞的细胞溶解能力与刺激细胞、效应细胞和靶淋巴细胞之间不相容性所引入的HL - A（LA和FOUR）抗原数量呈正相关。然而，并非所有细胞溶解情况都能由HL - A系统解释这一事实强调，其他特异性抗原（靶决定簇）可能会干扰细胞介导的淋巴细胞溶解。
