羟乙基淀粉对体外血小板和粒细胞功能的影响。

The effect of hydroxyethyl starch on in vitro platelet and granulocyte function.

作者信息

Schiffer C A, Aisner J, Schmukler M, Whitaker C L, Wolff J H

出版信息

Transfusion. 1975 Sep-Oct;15(5):473-5. doi: 10.1046/j.1537-2995.1975.15576082223.x.

DOI:10.1046/j.1537-2995.1975.15576082223.x

Abstract

The effect of hydroxyethyl starch (HES) on granulocyte and platelet functions was assessed. No alteration of granulocyte viability, morphology, phagocytic ability, or bactericidal capacity was detected after incubation with 6 per cent HES at 25 C for two hours. Platelet morphology, size distribution, aggregation, nucleotide and serotonin release, and platelet factor-3 availability were also unchanged after exposure to HES. It is concluded that HES has no adverse effect on cell function and appears to be a suitable adjuvant agent for blood cell component collection.

摘要

评估了羟乙基淀粉（HES）对粒细胞和血小板功能的影响。在25℃下将粒细胞与6%的HES孵育两小时后，未检测到粒细胞活力、形态、吞噬能力或杀菌能力的改变。暴露于HES后，血小板形态、大小分布、聚集、核苷酸和5-羟色胺释放以及血小板因子3的可用性也未发生变化。得出的结论是，HES对细胞功能没有不良影响，似乎是血细胞成分采集的合适佐剂。