Iogannsen M G, Khudoleĭ V V
Vopr Onkol. 1975;21(4):45-50.
In a chamber for intra vital microscopy, implanted subcutaneously in a rat, stained rat lymphosarcoma cells were applied into a preliminary formed connective tissue layer. The process of intracellular transformation of a dye and its elimination from the cytoplasm was observed. Following elimination of the dye a duplication of lymphosarcoma cells would proceed. This is a very intensive process, and after 5-7 days the connective tissue is completely substituted by tumor cells.
