妊娠贫血对人胎盘细胞生长的影响。

Effect of pregnancy anaemia on cellular growth in the human placenta.

作者信息

Marwah P, Singla P N, Krishna M, Agarwal K N

出版信息

Acta Paediatr Scand. 1979 Nov;68(6):899-901. doi: 10.1111/j.1651-2227.1979.tb08230.x.

DOI:10.1111/j.1651-2227.1979.tb08230.x

Abstract

The effects of pregnancy anaemia on cell number and size in human placentae were investigated. Total organ weight, protein, RNA and DNA contents were determined in 54 fresh placentae from anaemic women (haemoglobin less than 110 g/l) and another 32 placentae from women without anaemia (haemoglobin greater than or equal to 110 g/l). The placental weight was significantly reduced in pregnancy anaemia. The decrease in total placental DNA in anaemic women suggested that the reduced placental weight was due to a decrease in cell number. However, these placentae also showed evidence of compensatory cellular hypertrophy as indicated by increase in both weight per cell and protein per cell.

摘要

研究了妊娠贫血对人胎盘细胞数量和大小的影响。测定了54例贫血妇女（血红蛋白低于110 g/l）新鲜胎盘以及另外32例非贫血妇女（血红蛋白大于或等于110 g/l）胎盘的总器官重量、蛋白质、RNA和DNA含量。妊娠贫血时胎盘重量显著降低。贫血妇女胎盘总DNA减少表明胎盘重量减轻是由于细胞数量减少。然而，这些胎盘也显示出代偿性细胞肥大的证据，表现为每细胞重量和每细胞蛋白质增加。