Jones A W, Goldberg L, Neri A
Acta Pharmacol Toxicol (Copenh). 1979 Nov;45(5):345-51. doi: 10.1111/j.1600-0773.1979.tb02403.x.
The effects of a sugar mixture containing 43% glucose and 36% fructose on ethanol metabolism and on ethanol-induced impairment were studied in intact rats. When ethanol was given orally mixed with the sugars there was a significant reduction in the area of the blood alcohol time curve accompanied by a decrease in the peak ethanol concentration and a slowing in the rate of ethanol absorption. The whole curve followed a lower course and the time for complete removal of ethanol from the body was markedly reduced even though the slope of the elimination phase (beta) was not significantly increased. Ethanol-induced impairment as measured using a tilting plane device was significantly less when ethanol was given mixed with the sugars and paralleled the reduced area and duration of the blood alcohol curve. The magnitude of the effect observed on blood alcohol levels and impairment was dependent on the dose of sugars administered in relation to the alcohol dose. When the sugars were given orally after absorption and distribution of ethanol were complete the slope of the elimination phase (beta) was increase by 30%. These findings point to an increased rate of ethanol metabolism in rats in the presence of sugars. The action of the sugars prevails only for the first few hours after administration thereafter the rate of ethanol metabolism returns to normal.
在完整的大鼠中研究了含有43%葡萄糖和36%果糖的糖混合物对乙醇代谢及乙醇所致损伤的影响。当乙醇与这些糖混合口服时，血醇时间曲线的面积显著减小，同时乙醇峰值浓度降低，乙醇吸收速率减慢。整个曲线处于较低水平，即使消除相（β）的斜率没有显著增加，但乙醇从体内完全清除的时间也明显缩短。当乙醇与糖混合给予时，使用倾斜平面装置测量的乙醇所致损伤显著减轻，且与血醇曲线面积和持续时间的减少相一致。观察到的对血醇水平和损伤的影响程度取决于相对于酒精剂量给予的糖剂量。当在乙醇吸收和分布完成后口服糖时，消除相（β）的斜率增加了30%。这些发现表明在有糖存在的情况下大鼠乙醇代谢速率增加。糖的作用仅在给药后的最初几个小时占优势，此后乙醇代谢速率恢复正常。
