Bailenger J, Souby J
Ann Parasitol Hum Comp. 1979 Mar-Apr;54(2):227-35.
The variations in corticosteronemy induced by the development of Stronglyoides ratti in the Rat can be detected both in the afternoon, when corticosteronemy reaches its maximum, and in the morning when it is at its lowest rate. Nevertheless, hypercorticosteronemy, which is at its maximum 48 hours after infestation, is more sensible in the morning, whereas on the contrary hypocorticosteronemy is more significant in the afternoon and then shows a sudden and very important drop which seems to coincide with the beginning of the expulsion of the adult worms. According to previous results, inhibition of the secretion of gluco-cortico-steroids is caused by the worms; furthermore, Ogilvie and Jones show the determinant role of sensitized lymphocytes, for the expulsion of antibody-damaged worms, whereas some authors suggest that eosinophils act as cytotoxic cells on sensitized helminths; the hypothesis may therefore be put forward that hypocorticosteronemy liberates the intervention of active lymphocytes and eosinophils, triggering so the phenomenon of spontaneous deparasiting.
大鼠感染鼠类圆线虫后所诱导的皮质酮水平变化，在下午（此时皮质酮水平达到最高）和上午（此时皮质酮水平处于最低速率）均可检测到。然而，感染后48小时达到峰值的高皮质酮血症在上午更为明显，相反，低皮质酮血症在下午更为显著，随后会出现突然且非常显著的下降，这似乎与成虫排出的开始相吻合。根据先前的结果，蠕虫会导致糖皮质激素分泌受到抑制；此外，奥格尔维（Ogilvie）和琼斯（Jones）表明致敏淋巴细胞在抗体损伤蠕虫的排出中起决定性作用，而一些作者认为嗜酸性粒细胞对致敏蠕虫起细胞毒性作用；因此可以提出这样的假设，即低皮质酮血症会释放活性淋巴细胞和嗜酸性粒细胞的干预作用，从而引发自发驱虫现象。
