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钙离子对分离肝细胞中乙醇氧化及药物葡萄糖醛酸化的影响。

Effect of calcium ions on ethanol oxidation and drug glucuronidation in isolated hepatocytes.

作者信息

Andersson B, Jones D P, Orrenius S

出版信息

Biochem J. 1979 Dec 15;184(3):709-11. doi: 10.1042/bj1840709.

DOI:10.1042/bj1840709
PMID:540060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1161859/
Abstract

The effect of extracellular Ca2+ concentration on ethanol oxidation and drug metabolism was studied in isolated rat hepatocytes. Both ethanol oxidation and drug glucuronidation showed similar dependence upon Ca2+, which was a stimulation of activity as Ca2+ was increased to physiological concentration, and inhibition at higher concentration.

摘要

在分离的大鼠肝细胞中研究了细胞外钙离子浓度对乙醇氧化和药物代谢的影响。乙醇氧化和药物葡萄糖醛酸化对钙离子均表现出相似的依赖性，即随着钙离子浓度增加至生理浓度时活性受到刺激，而在更高浓度时受到抑制。

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1
Effect of calcium ions on ethanol oxidation and drug glucuronidation in isolated hepatocytes.钙离子对分离肝细胞中乙醇氧化及药物葡萄糖醛酸化的影响。
Biochem J. 1979 Dec 15;184(3):709-11. doi: 10.1042/bj1840709.
2
Kinetics of sulfation and glucuronidation of harmol in the perfused rat liver preparation. Disappearance of aberrances in glucuronidation kinetics by inhibition of sulfation.灌注大鼠肝脏制剂中去甲骆驼蓬碱的硫酸化和葡萄糖醛酸化动力学。通过抑制硫酸化消除葡萄糖醛酸化动力学中的异常现象。
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Normal and retrograde perfusion to probe the zonal distribution of sulfation and glucuronidation activities of harmol in the perfused rat liver preparation.采用正向和逆向灌注法，探究灌注大鼠肝脏制剂中去甲骆驼蓬碱硫酸化和葡萄糖醛酸化活性的区域分布。
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Sulphate and glucuronic acid conjugation of harmol in human fetal and adult liver tissue.去甲骆驼蓬碱在人胎儿及成人肝脏组织中的硫酸化和葡萄糖醛酸化结合反应
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Effect of glucagon on ethanol oxidation in isolated rat liver cells.胰高血糖素对离体大鼠肝细胞乙醇氧化的影响。
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引用本文的文献

1
Intraluminal calcium of the liver endoplasmic reticulum stimulates the glucuronidation of p-nitrophenol.肝内质网腔内的钙会刺激对硝基苯酚的葡萄糖醛酸化。
Biochem J. 1993 May 15;292 ( Pt 1)(Pt 1):99-104. doi: 10.1042/bj2920099.

本文引用的文献

1
The effects of Ca(2+) and ADP on the activity of NAD-linked isocitrate dehydrogenase of muscle.钙离子和二磷酸腺苷对肌肉中与烟酰胺腺嘌呤二核苷酸相关的异柠檬酸脱氢酶活性的影响。
FEBS Lett. 1969 Oct 21;5(2):124-126. doi: 10.1016/0014-5793(69)80311-x.
2
Regulation of the mitochondrial oxidation-reduction state in intact hepatocytes by calcium ions.钙离子对完整肝细胞中线粒体氧化还原状态的调节作用。
Biochem Biophys Res Commun. 1974 Nov 27;61(2):743-50. doi: 10.1016/0006-291x(74)91020-1.
3
Metabolic interaction of ethanol and alprenolol in isolated liver cells.
Acta Pharmacol Toxicol (Copenh). 1975 Sep;37(3):185-200. doi: 10.1111/j.1600-0773.1975.tb00835.x.
4
Ca2+ transport across plasma and mitochondrial membranes of isolated hepatocytes.钙离子跨分离肝细胞的质膜和线粒体膜的转运。
FEBS Lett. 1975 Nov 1;59(1):39-43. doi: 10.1016/0014-5793(75)80336-x.
5
Rate-limiting factors in the oxidation of ethanol by isolated rat liver cells.分离的大鼠肝细胞对乙醇氧化的限速因素。
Biochem J. 1975 Aug;150(2):205-9. doi: 10.1042/bj1500205.
6
Isolation and use of liver cells.肝细胞的分离与应用。
Methods Enzymol. 1978;52:60-71. doi: 10.1016/s0076-6879(78)52006-5.
7
The divalent cation requirement of the mitochondrial glycerol-3-phosphate dehydrogenase.
Biochim Biophys Acta. 1977 Oct 12;462(1):102-12. doi: 10.1016/0005-2728(77)90192-x.
8
Ethanol: modifications of acute intoxication by divalent cations.
Science. 1978 Mar 17;199(4334):1219-21. doi: 10.1126/science.343251.
9
Interaction of ethanol oxidation with glucuronidation in isolated hepatocytes.
Biochem Pharmacol. 1978;27(22):2583-8. doi: 10.1016/0006-2952(78)90331-3.
10
Calcium-mediated alterations in the oxidation-reduction state of pyridine nucleotidesin isolated liver cells.
FEBS Lett. 1975 May 15;53(3):297-301. doi: 10.1016/0014-5793(75)80040-8.