钙离子对分离肝细胞中乙醇氧化及药物葡萄糖醛酸化的影响。
Effect of calcium ions on ethanol oxidation and drug glucuronidation in isolated hepatocytes.
作者信息
Andersson B, Jones D P, Orrenius S
出版信息
Biochem J. 1979 Dec 15;184(3):709-11. doi: 10.1042/bj1840709.
Abstract
The effect of extracellular Ca2+ concentration on ethanol oxidation and drug metabolism was studied in isolated rat hepatocytes. Both ethanol oxidation and drug glucuronidation showed similar dependence upon Ca2+, which was a stimulation of activity as Ca2+ was increased to physiological concentration, and inhibition at higher concentration.
摘要
在分离的大鼠肝细胞中研究了细胞外钙离子浓度对乙醇氧化和药物代谢的影响。乙醇氧化和药物葡萄糖醛酸化对钙离子均表现出相似的依赖性，即随着钙离子浓度增加至生理浓度时活性受到刺激，而在更高浓度时受到抑制。
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