胰高血糖素对离体大鼠肝细胞乙醇氧化的影响。

Effect of glucagon on ethanol oxidation in isolated rat liver cells.

作者信息

Mangeney-Andréani M, Beaugé F, Nordmann J, Nordmann R

出版信息

Experientia. 1981 Jun;37(6):545-6. doi: 10.1007/BF01990039.

DOI:10.1007/BF01990039

Abstract

Addition of glucagon 5 min after ethanol was found to stimulate the rate of ethanol oxidation in hepatocytes isolated from starved rats. This stimulation is of the same order of magnitude as that mediated by asparagine. The glucagon effect is suppressed by antiproteolytic agents such as insulin or NH4Cl. The stimulating effect of glucagon on ethanol oxidation is probably linked to enhanced proteolysis and an elevated glutamate level in the hepatocytes.

摘要

研究发现，在给饥饿大鼠分离的肝细胞注射乙醇5分钟后添加胰高血糖素，可刺激乙醇氧化速率。这种刺激作用的量级与天冬酰胺介导的刺激作用相同。胰高血糖素的作用被抗蛋白水解剂（如胰岛素或氯化铵）所抑制。胰高血糖素对乙醇氧化的刺激作用可能与肝细胞中蛋白水解增强和谷氨酸水平升高有关。