人类及几种哺乳动物甲胎蛋白之间的免疫学与化学相关性。

Immunological and chemical correlation between alpha-fetoproteins from human and several mammalian species.

作者信息

Nishi S, Watabe H, Hirai H

出版信息

Ann N Y Acad Sci. 1975 Aug 22;259:109-18. doi: 10.1111/j.1749-6632.1975.tb25407.x.

DOI:10.1111/j.1749-6632.1975.tb25407.x

Abstract

Alpha-Fetoproteins of several animals were purified and their molecular weights, amino acid compositions and peptide maps were compared, demonstrating the close similarities. These data indicated that the alpha-fetoproteins of mammalian species have closely related antigenical and chemical structures. Rabbits and horses were immunized with human alpha-fetoprotein, and it was observed that the animals produced antibodies reaction not only with human alpha-fetoprotein but with their homologous alpha-fetoproteins. The results were interpreted as the breakdown of the tolerance to their own alpha-fetoprotein.

摘要

几种动物的甲胎蛋白被提纯，并对其分子量、氨基酸组成和肽图进行了比较，结果显示出密切的相似性。这些数据表明，哺乳动物的甲胎蛋白具有密切相关的抗原和化学结构。用人类甲胎蛋白对兔子和马进行免疫，结果发现这些动物产生的抗体不仅与人甲胎蛋白发生反应，还与其同源甲胎蛋白发生反应。这些结果被解释为对自身甲胎蛋白耐受性的破坏。