幼年自发性高血压大鼠肾脏中去甲肾上腺素的释放增强。

Enhanced release of noradrenaline in the kidney of the young spontaneously hypertensive rat.

Collis M G, de May C, Vanhoutte P M

Clin Sci (Lond). 1979 Dec;57 Suppl 5:233s-234s. doi: 10.1042/cs057233s.

Abstract

Vascular reactivity and noradrenaline overflow were studied in Tyrode solution-perfused kidneys from young (6 weeks) normotensive and spontaneously hypertensive (SH) rats. 2. The vasoconstrictor response to nerve stimulation was greater in the kidneys from young SH rats than in those from young control rats. 3. Nerve stimulation evoked a greater release of noradrenaline in the kidneys from young SH rats than in those from normotensive animals. 4. The results demonstrate that the renal sympathetic nerves release more noradrenaline than normal in the young SH rats, which could be an important factor in causing hypertension.

摘要

研究了来自年轻（6周龄）正常血压和自发性高血压（SH）大鼠的经台氏液灌注肾脏的血管反应性和去甲肾上腺素溢出情况。2. 年轻SH大鼠肾脏对神经刺激的血管收缩反应比年轻对照大鼠的更大。3. 神经刺激在年轻SH大鼠肾脏中诱发的去甲肾上腺素释放比在正常血压动物的肾脏中更多。4. 结果表明，年轻SH大鼠的肾交感神经释放的去甲肾上腺素比正常情况更多，这可能是导致高血压的一个重要因素。