自发性高血压发展过程中离体灌注肾脏的神经元和血管反应性

Neuronal and vascular reactivity in isolated perfused kidneys during the development of spontaneous hypertension.

Collis M G, Vanhoutte P M

Clin Sci Mol Med Suppl. 1978 Dec;4:233s-235s. doi: 10.1042/cs055233s.

Abstract

Vascular reactivity was studied in Tyrode solution perfused kidneys from young (7 weeks) and mature (4-6 months) spontaneously hypertensive rats (SH rats). 2. The response to nerve stimulation was greater in the kidneys from young SH rats than in those from young control rats, both in control solution and after inhibition of the disposition of noradrenaline; both groups exhibited the same sensitivity to noradrenaline, angiotensin II and barium chloride. 3. The response to nerve stimulation was normal in kidneys from mature SH rats, but responses to noradrenaline, angiotensin II and barium chloride were greater than the control. 4. Cocaine potentiated the response to nerve stimulation more in the kidneys from mature SH rats than in those from the control rats. 5. The results suggest that renal sympathetic nerves release more noradrenaline than normal in the young SH rats, which could be an important factor in causing hypertension. 6. In the established phase of spontaneous hypertension the vascular reactivity to exogenous agonists is increased, probably as a consequence of high blood pressure; the more efficient neuronal uptake causes normalization of the response to sympathetic nerve stimulation.

摘要

在以台氏液灌注的幼年（7周龄）和成年（4 - 6月龄）自发性高血压大鼠（SH大鼠）的肾脏中研究血管反应性。2. 在对照溶液中以及抑制去甲肾上腺素代谢后，幼年SH大鼠肾脏对神经刺激的反应比幼年对照大鼠的更强；两组对去甲肾上腺素、血管紧张素II和氯化钡表现出相同的敏感性。3. 成年SH大鼠肾脏对神经刺激的反应正常，但对去甲肾上腺素、血管紧张素II和氯化钡的反应比对照大鼠更强。4. 可卡因对成年SH大鼠肾脏神经刺激反应的增强作用比对对照大鼠肾脏的更强。5. 结果表明，幼年SH大鼠肾交感神经释放的去甲肾上腺素比正常情况更多，这可能是导致高血压的一个重要因素。6. 在自发性高血压的发病期，对外源性激动剂的血管反应性增加，这可能是高血压的结果；更有效的神经元摄取使对交感神经刺激的反应恢复正常。