Böttiger L E
Haematol Blood Transfus. 1979;24:27-37. doi: 10.1007/978-3-642-67483-9_4.
Epidemiological data show that the incidence of aplastic anemia is a least 4-5 times as high in the far East as in the West. The reason seems to be complex--a number of exogenic factors act against a background of genetic differences in susceptibility. A Swedish study of aplastic anemia shows the overall incidence to be 13 cases per million inhabitants and year, but also that the incidence varies greatly with age (range 4-61 cases per million). Drugs are the single most important aetiologic factor. Chloramphenicol is the most common offender, but in many countries it now has been replaced by the anti-inflammatory agents phenylbutazone and oxyphenbutazone. In Sweden the latter also have disappeared and sulfonamide preparations dominate among drugs causing aplasia.
流行病学数据显示，再生障碍性贫血的发病率在远东地区至少是西方的4至5倍。原因似乎很复杂——许多外源性因素在易感性存在遗传差异的背景下起作用。瑞典一项关于再生障碍性贫血的研究表明，总体发病率为每百万居民每年13例，但发病率也随年龄有很大差异（范围为每百万4至61例）。药物是唯一最重要的病因因素。氯霉素是最常见的致病药物，但在许多国家，它现在已被抗炎药保泰松和羟保泰松所取代。在瑞典，后两种药物也已消失，在导致再生障碍性贫血的药物中，磺胺类制剂占主导地位。
