Trautmann M, Krause B, Birnbaum D, Wagner J, Lenk V
Eur J Clin Microbiol. 1986 Jun;5(3):297-302. doi: 10.1007/BF02017785.
The bactericidal activity of two newer quinolones, ciprofloxacin and ofloxacin, against eight strains of Salmonella typhi was examined by the serum dilution test and studies of bacterial killing kinetics in human serum, and compared to standard regimens. Bactericidal titers for ciprofloxacin ranged from 1:388 to 1:119 two hours and from 1:119 to 1:57 six hours after volunteers received an oral dose of 500 mg. The respective titers obtained after a 200 mg oral dose of ofloxacin were somewhat lower, but still exceeded 1:16 in all instances. Studies of bacterial killing kinetics demonstrated a rapid bactericidal action of both drugs against all strains tested. Compared to the classical anti-typhoid agents chloramphenicol, cotrimoxazole and amoxicillin, the new quinolones showed both markedly higher bactericidal titers and more rapid killing of Salmonella typhi in human serum.
通过血清稀释试验以及对人血清中细菌杀灭动力学的研究，检测了两种新型喹诺酮类药物环丙沙星和氧氟沙星对8株伤寒沙门氏菌的杀菌活性，并与标准治疗方案进行了比较。志愿者口服500mg环丙沙星后两小时，杀菌效价范围为1:388至1:119，六小时后为1:119至1:57。口服200mg氧氟沙星后获得的相应效价略低，但在所有情况下仍超过1:16。细菌杀灭动力学研究表明，这两种药物对所有测试菌株均有快速杀菌作用。与经典的抗伤寒药物氯霉素、复方新诺明和阿莫西林相比，新型喹诺酮类药物在人血清中对伤寒沙门氏菌的杀菌效价明显更高，杀菌速度也更快。
