Nakamura M, Yokoyama T, Shirasawa Y, Hirai K, Sano N
Nihon Yakurigaku Zasshi. 1979 Jul;75(5):487-494. doi: 10.1254/fpj.75.487.
Effects of adenosine triphosphate (ATP) on the postrotatory-induced nystagmus in rabbits and disorders of vestibular function induced by repeated administration of streptomycin in guinea pigs were studied. ATP-2Na exerted little influence on the postrotatory nystagmus in doses of 3 and 10 mg/kg, i.v., while slight suppressive effects were noted with a dose of 30 mg/kg. On the other hand, diphenidol hydrochloride remarkably suppressed the postrotatory nystagmus in a dose of 3 mg/kg i.v.. The disturbance in vestibular function following administration of streptomycin sulfate (400 mg/kg i.m., once daily x 9) was significantly alleviated when concomitant treatment with ATP-2Na (3 mg/kg i.p., 10 mg/kg i.p. and 100 mg/kg p.o., once daily x 14) or diphenidol hydrochloride (50 mg/kg p.o., once daily x 14) was given. ATP as well as diphenidol alleviated disorders in the vestibular function, while ATP had little influence on vestibular function in intact animals.
研究了三磷酸腺苷（ATP）对家兔旋转后眼震以及对豚鼠反复注射链霉素所致前庭功能障碍的影响。静脉注射剂量为3和10mg/kg的ATP-2Na对旋转后眼震几乎没有影响，而30mg/kg剂量时则有轻微抑制作用。另一方面，静脉注射剂量为3mg/kg的盐酸地芬尼多能显著抑制旋转后眼震。当同时给予ATP-2Na（腹腔注射3mg/kg、10mg/kg和口服100mg/kg，每日1次，共14天）或盐酸地芬尼多（口服50mg/kg，每日1次，共14天）时，硫酸链霉素（肌肉注射400mg/kg，每日1次，共9次）给药后引起的前庭功能紊乱得到显著缓解。ATP和地芬尼多均能减轻前庭功能障碍，而ATP对正常动物的前庭功能几乎没有影响。
