Shiozaki S, Kubo K, Shuto K, Oka T, Nakamizo N
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
Acta Otolaryngol Suppl. 1988;460:50-60. doi: 10.3109/00016488809125135.
The effects of flunarizine on induced nystagmus and cochlear blood flow were compared with those of cinnarizine and diphenidol. Flunarizine significantly inhibited caloric (cool water)-induced nystagmus frequency and duration of nystagmus in rabbits at 5 mg/kg i.v., whereas cinnarizine and diphenidol only slightly decreased the frequency of nystagmus at 5 mg/kg, i.v. As for optokinetic stimuli-induced nystagmus in rabbits, flunarizine significantly decreased the amplitude of nystagmus at 2.5 mg/kg i.v., and cinnarizine and diphenidol inhibited nystagmus at 5 mg/kg, i.v. Flunarizine had no effect on nystagmus induced by electrical stimulation of the lateral geniculate body in rabbits at doses up to 5 mg/kg, i.v. Flunarizine increased the cochlear blood flow in anesthetized guinea pigs dose-dependently (0.312-1.25 mg/kg i.v.) On the other hand, cinnarizine (0.625-2.5 mg/kg i.v.) and diphenidol (0.625-2.5 mg/kg i.v.) increased cochlear blood flow, but the duration of action of both cinnarizine and diphenidol was shorter than that of flunarizine at the same dose. As stated above, flunarizine inhibited nystagmus experimentally induced by caloric or optokinetic stimuli. Increased cochlear blood flow suggested that the enhancement of vestibular blood flow might play an important role in the treatment of vestibular dysfunctions with this drug.
将氟桂利嗪对诱发性眼球震颤和耳蜗血流量的影响与桂利嗪和地芬尼多进行了比较。静脉注射5mg/kg时，氟桂利嗪可显著抑制家兔由冷热水（冷水）诱发的眼球震颤频率和震颤持续时间，而静脉注射5mg/kg时，桂利嗪和地芬尼多仅略微降低眼球震颤频率。至于家兔视动刺激诱发的眼球震颤，静脉注射2.5mg/kg时，氟桂利嗪可显著降低眼球震颤幅度，静脉注射5mg/kg时，桂利嗪和地芬尼多可抑制眼球震颤。静脉注射剂量高达5mg/kg时，氟桂利嗪对家兔外侧膝状体电刺激诱发的眼球震颤无影响。氟桂利嗪可使麻醉豚鼠的耳蜗血流量呈剂量依赖性增加（静脉注射0.312 - 1.25mg/kg）。另一方面，桂利嗪（静脉注射0.625 - 2.5mg/kg）和地芬尼多（静脉注射0.625 - 2.5mg/kg）可增加耳蜗血流量，但在相同剂量下，桂利嗪和地芬尼多的作用持续时间均短于氟桂利嗪。如上所述，氟桂利嗪可抑制由冷热刺激或视动刺激实验性诱发的眼球震颤。耳蜗血流量增加表明，前庭血流量的增加可能在该药物治疗前庭功能障碍中起重要作用。
