Cook J D, Marsaglia G, Eschbach J W, Funk D D, Finch C A
J Clin Invest. 1970 Feb;49(2):197-205. doi: 10.1172/JCI106228.
A method is presented for calculating internal iron kinetics. An early reflux associated with extravascular exchange and a late reflux associated with erythropoiesis are described. A biologic model of iron exchange is proposed in which erythron iron turnover is divided into an effective portion (iron fixed in circulating red cells) and wastage iron of erythropoiesis (late reflux). Nonerythroid iron exchange also has a fixed portion (parenchymal uptake) and an early reflux (lymphatic circuit), both of which correlate in amount with the amount of plasma iron. Ferrokinetic measurements in normal subjects and in various pathologic states are presented to validate the model.
本文提出了一种计算体内铁动力学的方法。描述了与血管外交换相关的早期反流和与红细胞生成相关的晚期反流。提出了一种铁交换的生物学模型，其中红细胞铁周转分为有效部分（固定在循环红细胞中的铁）和红细胞生成的损耗铁（晚期反流）。非红细胞铁交换也有一个固定部分（实质摄取）和早期反流（淋巴循环），两者在数量上均与血浆铁量相关。文中展示了正常受试者和各种病理状态下的铁动力学测量结果，以验证该模型。
