Tunac J B, McDaniel L E, Schaffner C P
J Antibiot (Tokyo). 1979 Dec;32(12):1223-9. doi: 10.7164/antibiotics.32.1223.
A soil isolate of Streptomyces, which has been deposited in the culture collection of the Waksman Institute of Microbiology, Rutgers University as IMRU 3962, produces a new heptaene macrolide antifungal antibiotic, hydroheptin. The producing microorganism, which co-produces the antibiotic, chartreusin, has been identified as a strain of Streptomyces chartreusis. Fermentation and bioassay procedures were developed for the production and analysis of hydroheptin and chartreusin. Isolation and purification procedures based on solvent extraction and precipitation of an organic acid yielded a relatively pure product of hydroheptin.
一种链霉菌的土壤分离物，已作为IMRU 3962保藏于罗格斯大学瓦克斯曼微生物学研究所的培养物保藏中心，它产生一种新的七烯大环内酯类抗真菌抗生素——氢化制霉菌素。产生抗生素的微生物还产生抗生素金丝菌素，已被鉴定为金色链霉菌菌株。已开发出用于生产和分析氢化制霉菌素及金丝菌素的发酵和生物测定程序。基于有机溶剂萃取和有机酸沉淀的分离纯化程序得到了相对纯净的氢化制霉菌素产品。
