Alison R E, Whitelaw D M
Can Med Assoc J. 1970 Feb 14;102(3):278-80.
In a crossover study the effectiveness of intermittent maintenance doses of nitrogen mustard was compared to that of vinblastine sulfate in the treatment of 61 patients with advanced Hodgkin's disease. Forty-five of the patients had had previous radiation therapy. Nine of 29 patients who received nitrogen mustard as the first drug had a complete response and five had a partial response. The comparative results in 32 patients receiving vinblastine sulfate first were nine complete responses and 13 partial responses. The median duration of the complete responses to each drug was 43 weeks. The partial responses were of shorter duration. When the second drug was given in adequate doses, almost as many patients responded with a similar median duration of response.It is concluded that nitrogen mustard and vinblastine sulfate are equally effective single agents in the treatment of patients with advanced Hodgkin's disease and that patient preference would favour vinblastine sulfate because of its negligible side effects.
在一项交叉研究中，将间歇维持剂量的氮芥与硫酸长春碱治疗61例晚期霍奇金病患者的有效性进行了比较。其中45例患者曾接受过放射治疗。29例首先接受氮芥治疗的患者中有9例完全缓解，5例部分缓解。32例首先接受硫酸长春碱治疗的患者的比较结果为9例完全缓解和13例部分缓解。每种药物完全缓解的中位持续时间为43周。部分缓解的持续时间较短。当给予第二种药物足够剂量时，几乎同样多的患者出现反应，且反应的中位持续时间相似。得出的结论是，氮芥和硫酸长春碱在治疗晚期霍奇金病患者方面是同样有效的单一药物，并且由于硫酸长春碱的副作用可忽略不计，患者更倾向于选择它。
