Butler K R
Can Med Assoc J. 1965 Oct 2;93(14):735-9.
Eleven patients with established Hodgkin's disease were treated with vinblastine sulfate. Each patient received from 0.15 to 0.20 mg./kg. of body weight intravenously in 10 divided doses over a five-hour period as initial therapy. All had received one or more of the more established forms of treatment before being given vinblastine. The response to treatment with vinblastine was excellent in three patients, good in one, and poor in three; there was no response in four. The longest remission was 15 months. Two of the patients were father and son. The side effects of treatment in this series included alopecia, leukopenia, and septicemia.
11例确诊为霍奇金病的患者接受了硫酸长春碱治疗。每位患者作为初始治疗，在5小时内静脉注射0.15至0.20毫克/千克体重，分10次给药。所有患者在接受长春碱治疗前均接受过一种或多种更成熟的治疗方式。长春碱治疗的反应在3例患者中为优，1例为良，3例为差；4例无反应。最长缓解期为15个月。其中2例患者为父子。该系列治疗的副作用包括脱发、白细胞减少和败血症。
