Choi J H
Can Med Assoc J. 1970 Feb 14;102(3):283-5.
An antiserum was produced against the plasma of rats with adrenal regeneration hypertension. When the antiserum was adsorbed with normal rat plasma a single precipitin arc in the pre-albumin zone remained in the antiserum, indicating a specific antibody against the hypertensive factors responsible for this type of hypertension in rats. Following a single injection of the adsorbed antiserum into rats with adrenal regeneration hypertension, the level of blood pressure dropped noticeably. Histologically, the zona glomerulosa of hypertensive rats was hyperplastic, whereas that of rats receiving the antiserum showed marked atrophy.
制备了一种针对肾上腺再生性高血压大鼠血浆的抗血清。当该抗血清用正常大鼠血浆吸附后，抗血清中在前白蛋白区仍保留一条单一的沉淀弧，这表明存在针对导致大鼠这种类型高血压的高血压因子的特异性抗体。给肾上腺再生性高血压大鼠单次注射吸附后的抗血清后，血压水平显著下降。组织学检查显示，高血压大鼠的肾小球带增生，而接受抗血清的大鼠的肾小球带则出现明显萎缩。
