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糖尿病视网膜病变中壁内周细胞的退变。

Degeneration of intramural pericytes in diabetic retinopathy.

作者信息

Addison D J, Garner A, Ashton N

出版信息

Br Med J. 1970 Jan 31;1(5691):264-6. doi: 10.1136/bmj.1.5691.264.

DOI:10.1136/bmj.1.5691.264
PMID:5416614
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1699396/
Abstract

Retinal pericyte degeneration, a usual finding in diabetic retinopathy, has been shown to be a change probably peculiar to the retina rather than part of a more widespread angiopathy. Thus in a patient with diabetic retinopathy the characteristic eosinophilic degeneration of the pericyte nuclei ceased at the optic disc and could not be found in vessels of the optic nerves and brain.

摘要

视网膜周细胞变性是糖尿病视网膜病变中的常见表现,已被证明这可能是视网膜特有的变化,而非更广泛血管病变的一部分。因此,在患有糖尿病视网膜病变的患者中,周细胞核特征性的嗜酸性变性在视盘处停止,在视神经和脑部血管中未发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7913/1699396/f514067b8e21/brmedj02272-0030-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7913/1699396/80e136f10d56/brmedj02272-0029-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7913/1699396/7cae4d9948f3/brmedj02272-0029-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7913/1699396/218d1b705b2c/brmedj02272-0030-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7913/1699396/f514067b8e21/brmedj02272-0030-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7913/1699396/80e136f10d56/brmedj02272-0029-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7913/1699396/7cae4d9948f3/brmedj02272-0029-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7913/1699396/218d1b705b2c/brmedj02272-0030-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7913/1699396/f514067b8e21/brmedj02272-0030-b.jpg

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Degeneration of intramural pericytes in diabetic retinopathy.糖尿病视网膜病变中壁内周细胞的退变。
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[Comparative studies of capillary microscopy and retinal changes in diabetic patients].
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本文引用的文献

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Vascular changes in diabetes with particular reference to the retinal vessels; preliminary report.糖尿病中的血管变化,特别是视网膜血管;初步报告。
Br J Ophthalmol. 1949 Jul;33(7):407-20. doi: 10.1136/bjo.33.7.407.
2
OCULAR CHANGES IN MULTIPLE MYELOMATOSIS.多发性骨髓瘤的眼部变化
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OCULAR PATHOLOGY IN MACROGLOBULINAEMIA.巨球蛋白血症的眼部病理学
通过光谱域光学相干断层扫描评估Ins2(Akita)糖尿病小鼠视网膜层厚度的全局和局部改变。
J Ophthalmol. 2018 Feb 20;2018:7253498. doi: 10.1155/2018/7253498. eCollection 2018.
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Drug transport into the central nervous system: using newer findings about the blood-brain barriers.药物向中枢神经系统的转运:利用关于血脑屏障的新发现。
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5
Disturbance of inorganic phosphate metabolism in diabetes mellitus: its relevance to the pathogenesis of diabetic retinopathy.糖尿病中无机磷酸盐代谢紊乱:其与糖尿病视网膜病变发病机制的相关性。
J Ophthalmol. 2014;2014:135287. doi: 10.1155/2014/135287. Epub 2014 Mar 20.
6
Modes of Retinal Cell Death in Diabetic Retinopathy.糖尿病视网膜病变中视网膜细胞死亡的模式
J Clin Exp Ophthalmol. 2013 Oct 1;4(5):298. doi: 10.4172/2155-9570.1000298.
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Marrow-derived cells regulate the development of early diabetic retinopathy and tactile allodynia in mice.骨髓细胞调节小鼠早期糖尿病视网膜病变和触觉超敏反应的发生。
Diabetes. 2012 Dec;61(12):3294-303. doi: 10.2337/db11-1249. Epub 2012 Aug 24.
8
Basement membrane changes in capillaries of the ageing human retina.老年人视网膜毛细血管基底膜的改变。
Br J Ophthalmol. 2011 Sep;95(9):1316-22. doi: 10.1136/bjo.2011.204222. Epub 2011 May 23.
9
Pericytopathy: oxidative stress and impaired cellular longevity in the pancreas and skeletal muscle in metabolic syndrome and type 2 diabetes.血管周细胞病:代谢综合征和 2 型糖尿病患者胰腺和骨骼肌中的氧化应激和细胞寿命受损。
Oxid Med Cell Longev. 2010 Sep-Oct;3(5):290-303. doi: 10.4161/oxim.3.5.13653. Epub 2010 Sep 1.
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Mouse models of neurological disorders: a view from the blood-brain barrier.神经疾病的小鼠模型:从血脑屏障角度的审视
Biochim Biophys Acta. 2010 Oct;1802(10):881-8. doi: 10.1016/j.bbadis.2009.10.011. Epub 2009 Oct 29.
J Pathol Bacteriol. 1963 Oct;86:453-61. doi: 10.1002/path.1700860220.
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Retinal vascular patterns. III. Age, hypertension, absolute glaucoma, injury.视网膜血管形态。III. 年龄、高血压、绝对性青光眼、损伤。
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Retinal vascular patterns. IV. Diabetic retinopathy.视网膜血管形态。IV. 糖尿病性视网膜病变。
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Diabetes. 1966 Apr;15(4):233-50. doi: 10.2337/diab.15.4.233.