肾脏与尿激肽原酶之间的关系。
The relationship between kidney and urinary kininogenase.
作者信息
Nustad K
出版信息
Br J Pharmacol. 1970 May;39(1):73-86. doi: 10.1111/j.1476-5381.1970.tb09557.x.
Abstract
- Rat kidneys which were perfused with saline contained both kininogenase (KGA) and kininase activity. These activities were separated by gel filtration on a Sephadex G-100 column. The kininase activity was excluded from the column whereas the KGA activity was retained. Kidney KGA activity was primarily found in the sedimentable fraction of the homogenate.2. The kidney KGA activity was compared with the urinary KGA activity, and the following properties were found to be the same: molecular dimension, pH optimum, effect of inhibitors, and ability to liberate kinins from kininogens.3. A urinary sample collected over 24 h contained about 8 times the KGA activity found in the corresponding kidneys at the end of the collection period. The urine: kidney ratio for alkaline phosphatase was about 0.01.4. The ability of kidney and urinary samples to hydrolyse N-alpha-benzoyl-L-arginine ethyl ester (BAEE) at pH 8.5 paralleled the KGA activity.
摘要
用生理盐水灌注的大鼠肾脏含有激肽原酶（KGA）和激肽酶活性。这些活性通过在葡聚糖G - 100柱上进行凝胶过滤分离。激肽酶活性从柱中被洗脱出来，而KGA活性被保留。肾脏KGA活性主要存在于匀浆的可沉淀部分。
将肾脏KGA活性与尿液KGA活性进行比较，发现以下特性相同：分子尺寸、最适pH值、抑制剂的作用以及从激肽原释放激肽的能力。
收集24小时的尿液样本中所含的KGA活性约为收集期结束时相应肾脏中KGA活性的8倍。碱性磷酸酶的尿：肾比率约为0.01。
肾脏和尿液样本在pH 8.5时水解N-α-苯甲酰-L-精氨酸乙酯（BAEE）的能力与KGA活性平行。
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