肾脏中膜结合激肽释放酶和肾素的激活。
Activation of membrane-bound kallikrein and renin in the kidney.
作者信息
Nishimura K, Alhenc-Gelas F, White A, Erdös E G
出版信息
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4975-8. doi: 10.1073/pnas.77.8.4975.
Abstract
Rat kidney contains membrane-bound renin (EC 3.4.99.19) and kallikrein (EC 3.4.21.8). Kallikrein activity was measured by a spectrophotometric assay and renin by radioimmunoassay. Plasma membrane-bound kallikrein was activated by lysolecithin and by melittin, which was a more potent activator., This activation by mellitin was independent of calcium concentration. Mellitin was, however, a more potent activator of membrane-bound renin in the presence of calcium. Administration of aldosterone to rats for 6 days increased kallikrein activity in the renal homogenate and in the membrane-enriched fractions, whereas renin activity was not affected. It was proposed that kallikrein may also be located on the basal membrane of tubular epithelial cells, where aldosterone can enhance its activity.
摘要
大鼠肾脏含有膜结合肾素（EC 3.4.99.19）和激肽释放酶（EC 3.4.21.8）。通过分光光度法测定激肽释放酶活性，通过放射免疫分析法测定肾素活性。质膜结合的激肽释放酶可被溶血卵磷脂和蜂毒素激活，蜂毒素是一种更有效的激活剂。蜂毒素的这种激活作用与钙浓度无关。然而，在有钙存在的情况下，蜂毒素是膜结合肾素更有效的激活剂。给大鼠注射醛固酮6天可增加肾匀浆和富含膜的部分中的激肽释放酶活性，而肾素活性不受影响。有人提出，激肽释放酶也可能位于肾小管上皮细胞的基底膜上，醛固酮可在该处增强其活性。
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Proc Natl Acad Sci U S A. 1980 Aug;77(8):4975-8. doi: 10.1073/pnas.77.8.4975.
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