Pietra G G, Magno M, Johns L
Lymphology. 1979 Sep;12(3):165-76.
Histamine causes interstitial pulmonary edema, but whether this is the result of an increased permeability of the pulmonary circulation or only of the bronchial circulation remains to be determined. In order to selectively study the effect of histamine on the pulmonary circulation, we used an isolated perfused rabbit lung preparation because in this species, the bronchial circulation is poorly developed. Edema formation was assessed by continuously monitoring the weight of the lung perfused at constant pressure. These studies were supplemented by electron microscopic observations using hemoglobin as an ultrastructural tracer for microvascular permeability. We found that histamine (8.0 microgram base/100 ml of perfusate) did not cause lung weight to increase. Ultrastructural studies showed that histamine, at this dosage, did not cause a greater leakage of hemoglobin that occurred in the control lungs. Thus, we have concluded that histamine does not increase the permeability of the pulmonary microcirculation in the isolated perfused rabbit lung.
组胺可导致间质性肺水肿，但这是肺循环通透性增加的结果，还是仅仅是支气管循环通透性增加的结果，仍有待确定。为了选择性地研究组胺对肺循环的影响，我们使用了离体灌注兔肺标本，因为在这个物种中，支气管循环发育不良。通过持续监测恒压灌注的肺的重量来评估水肿形成情况。这些研究通过电子显微镜观察得到补充，使用血红蛋白作为微血管通透性的超微结构示踪剂。我们发现组胺（8.0微克碱基/100毫升灌注液）并未导致肺重量增加。超微结构研究表明，在此剂量下，组胺并未导致血红蛋白渗漏比对照肺中更严重。因此，我们得出结论，组胺不会增加离体灌注兔肺中肺微循环的通透性。
