Effect of RA233 on platelet function in vitro.
作者信息
Hassanein A A, Turpie A G, McNicol G P, Douglas A S
出版信息
Br Med J. 1970 Apr 11;2(5701):83-6. doi: 10.1136/bmj.2.5701.83.
Abstract
RA233, a new pyrimido-pyrimidine compound, is a powerful inhibitor of platelet function tested in vitro; it inhibits calcium and adenosine diphosphate (A.D.P.)-induced platelet aggregation, inhibits the retention of platelets by glass beads, decreases the release of platelet factor 3 by kaolin, and inhibits clot retraction. In some in-vitro systems RA233 is significantly more potent that its analogue RA433 in inhibiting platelet function.
摘要
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