一种嘧啶并嘧啶化合物对体外血小板行为的作用。
Action of a pyrimido-pyrimidine compound on platelet behaviour in vitro.
作者信息
Forbes C D, McNicol G P, Douglas A S
出版信息
Br Med J. 1969 May 24;2(5655):483-5. doi: 10.1136/bmj.2.5655.483.
Abstract
A pyrimido-pyrimidine compound (RA433) was found in vitro to be a significantly more potent inhibitor of platelet behaviour than the previously available pyrimido-pyrimidine compound RA8-dipyridamole. In a turbidimetric system RA433 inhibits platelet aggregation induced by adenosine diphosphate, collagen, and noradrenaline; further, in a glass-bead-column technique it is a powerful inhiitor of platelet adhesiveness.
摘要
一种嘧啶并嘧啶化合物（RA433）在体外被发现是一种比之前可用的嘧啶并嘧啶化合物RA8-双嘧达莫更有效的血小板行为抑制剂。在比浊法系统中，RA433可抑制由二磷酸腺苷、胶原蛋白和去甲肾上腺素诱导的血小板聚集；此外，在玻璃珠柱技术中，它是血小板黏附的强力抑制剂。
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2
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3
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Circ Res. 1964 Jul;15:83-8. doi: 10.1161/01.res.15.1.83.
4
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6
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7
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