Neugebauer W, Durst J, Mayer H R
Langenbecks Arch Chir. 1979 Nov;350(1):33-42. doi: 10.1007/BF01232093.
From 1957--1977 193 patients were treated at the surgical clinic of the University of Tübingen for carcinoma of the extrahepatic bile ducts. Gall bladder carcinoma made up 139 cases; 54 were of bile duct carcinoma. The tumors were no longer operable in two-thirds of the patients with extrahepatic bile ducts cancer. The life expectancy rate of five years for patients with gall bladder carcinoma held for 7%. Up to now only one patient with a bile duct malignancy has survived longer than five years. In the last decade essentially no improvement of median life expectancy has occurred despite improved operating techniques. Due to uncharacteristic, misleading upper abdominal symptoms, patients who suffer gall bladder or bile duct cancer are unfortunately accurately diagnosed only after the carcinoma has overcome organ borders or is already metastatic. There is reasonable hope for improved early prognosis of extrahepatic bile duct carcinoma with ERCP (Endoscopic Retrograde Cholangio-Pancreaticography) and computer-tomography. Because the possibility of a relationship between gall bladder stones and/or the chronic inflammation of gall bladder and bile ducts and the development of cancer is not out of the question, widespread prophylactic cholecystectomy and gall passage cleansing should be employed.
1957年至1977年期间,图宾根大学外科诊所对193例肝外胆管癌患者进行了治疗。其中胆囊癌139例,胆管癌54例。三分之二的肝外胆管癌患者的肿瘤已无法手术切除。胆囊癌患者的五年生存率为7%。到目前为止,只有一名胆管恶性肿瘤患者存活超过了五年。在过去十年中,尽管手术技术有所改进,但中位预期寿命基本上没有改善。由于胆囊或胆管癌患者的上腹部症状不典型且具有误导性,不幸的是,这些患者只有在癌症突破器官边界或已经发生转移后才被准确诊断出来。通过内镜逆行胰胆管造影术(ERCP)和计算机断层扫描,有望改善肝外胆管癌的早期预后。由于胆囊结石和/或胆囊及胆管的慢性炎症与癌症发生之间存在关联的可能性并非不存在,因此应广泛采用预防性胆囊切除术和胆管清理术。