Adaikan P G, Karim S M
Prostaglandins. 1979 Nov;18(5):787-91. doi: 10.1016/0090-6980(79)90098-4.
The effects of (a) 4, 5, 6-trinor-3, 7-inter-m-phenylene PGE1 methyl ester, (b) 4, 5, 6 trinor-3, 7-inter-m-phenylene 3 oxa PGE1 and (c) 4, 5, 6 trinor-3, 7-inter-m-phenylene 3 oxa PGE1 methyl ester on human and guinea pig respiratory tract muscle in vitro and in vivo have been studied. All the analogues relaxed the isolated preparations of guinea-pig tracheal chain, human tracheal, bronchial and bronchiolar muscles and decreased histamine-induced lung resistance in the anaesthetised guinea pig. On some preparations the effects of the analogues were more pronounced than those of PGE1. The results suggest that some of the inter-m-phenylene analogues of PGE1 may be bronchodilators in asthmatics.
研究了（a）4,5,6-三降-3,7-间亚苯基前列地尔甲酯、（b）4,5,6-三降-3,7-间亚苯基-3-氧杂前列地尔和（c）4,5,6-三降-3,7-间亚苯基-3-氧杂前列地尔甲酯在体外和体内对人和豚鼠呼吸道肌肉的作用。所有类似物均可使豚鼠气管链、人气管、支气管和细支气管肌肉的离体标本舒张，并降低麻醉豚鼠组胺诱导的肺阻力。在一些标本上，类似物的作用比前列地尔更明显。结果表明，一些前列地尔的间亚苯基类似物可能是哮喘患者的支气管扩张剂。
