Acetylsalicylic acid: no chromosome damage in human leukocytes.

Acetylsalicylic acid was added to cultures of human leukocytes at several time periods over a wide range of concentrations (0.1 to 300.0 micrograms per milliliter). Leukocytes were also cultured from human volunteers during the ingestion of two 300-milligram tablets four times daily (2400 milligrams per day) over a 1-month period. No significant increase in chromosome aberrations was detected in vitro or in vivo.