Blackburn R O, Clegg E J
Teratology. 1979 Dec;20(3):441-6. doi: 10.1002/tera.1420200313.
Pregnant mice were exposed to reduced atmospheric pressures ranging from 630 to 390 mm Hg during the pre-implantation and implantation periods and the numbers of embryos surviving 85 hours post coitum compared with those in litter-mate controls. Even at a pressure of 630 mm Hg (= 1,550 mm Hg) there was a significant fall in numbers of normal blastocysts and rise in abnormal forms before implantation, and implantation sites were reduced in number. The numbers of abnormal forms increased and implantation sites decreased at lower pressures, suggesting strongly that the hypoxia of reduce atmospheric pressure was responsible for the abnormalities observed. The pre-implantation period appears to be one during which the fertilised ovum is at particular risk, both of hypoxic damage and of failure to implant. Implantation may afford a degree of protection against hypoxia.
在着床前期和着床期，将怀孕小鼠暴露于630至390毫米汞柱的减压环境中，并将交配后85小时存活的胚胎数量与同窝对照小鼠进行比较。即使在630毫米汞柱（=1550毫米汞柱）的压力下，着床前正常囊胚数量也显著下降，异常形态的数量增加，着床部位数量减少。在更低的压力下，异常形态的数量增加，着床部位减少，这强烈表明减压环境下的缺氧是观察到的异常现象的原因。着床前期似乎是受精卵特别容易受到缺氧损伤和着床失败风险影响的时期。着床可能提供一定程度的缺氧保护。
