蛋白质缺乏以及滴滴涕和苯巴比妥对微粒体酶的诱导作用对氯仿和一种吡咯里西啶生物碱——倒千里光碱急性毒性的影响。
The effect of protein deficiency and microsomal enzyme induction by DDT and phenobarbitone on the acute toxicity of chloroform and a pyrrolizidine alkaloid, retrorsine.
作者信息
McLean A E
出版信息
Br J Exp Pathol. 1970 Jun;51(3):317-21.
Abstract
The sensitivity of rats to the lethal and hepatotoxic effects of chloroform and retrorsine is not altered by feeding low protein or protein-free diets. For retrorsine the lethal effect is not altered by injection of dicophane (DDT) to protein-depleted rats. DDT and phenobarbitone increase the lethal and hepatotoxic effects of chloroform in stock or protein-depleted rats. It seems likely that chloroform requires metabolism to exert its toxic effects, but other factors such as liver fat are also determinants of toxicity.
摘要
给予低蛋白或无蛋白饮食不会改变大鼠对氯仿和倒千里光碱的致死及肝毒性作用的敏感性。对于倒千里光碱，给蛋白质缺乏的大鼠注射滴滴涕（DDT）不会改变其致死作用。DDT和苯巴比妥会增强正常大鼠或蛋白质缺乏大鼠对氯仿的致死及肝毒性作用。氯仿似乎需要经过代谢才能发挥其毒性作用，但其他因素如肝脏脂肪也是毒性的决定因素。
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