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The effect of oral phenobarbitone on hepatic microsomal cytochrome P-450 and demethylation activity in rats fed normal and low protein diets.

作者信息

Marshall W J, McLean A E

出版信息

Biochem Pharmacol. 1969 Jan;18(1):153-7. doi: 10.1016/0006-2952(69)90020-3.

DOI:10.1016/0006-2952(69)90020-3
PMID:5769345
Abstract
摘要

相似文献

1
The effect of oral phenobarbitone on hepatic microsomal cytochrome P-450 and demethylation activity in rats fed normal and low protein diets.口服苯巴比妥对正常蛋白饮食和低蛋白饮食大鼠肝脏微粒体细胞色素P-450及脱甲基活性的影响。
Biochem Pharmacol. 1969 Jan;18(1):153-7. doi: 10.1016/0006-2952(69)90020-3.
2
The selective stimulation, inhibition, and physicochemical alteration of the 7- and 16-alpha-hydroxylases of 3-beta-hydroxyandrost-5-en-17-one and drug-metabolizing enzymes in hepatic microsomal fractions.3-β-羟基雄甾-5-烯-17-酮的7-α和16-α羟化酶以及肝微粒体部分中药物代谢酶的选择性刺激、抑制和物理化学改变。
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3
The effect of phenobarbitone treatment of rats and of protein deprivation on the capacity of liver slices to conjugate bilirubin.苯巴比妥治疗大鼠及蛋白质缺乏对肝切片结合胆红素能力的影响。
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4
Electron spin resonance of microsomal cytochromes. Correlation of the amount of CO-binding species with so-called microsomal e-x in microsomes of of Sudan III-treated animals.
Arch Biochem Biophys. 1967 Sep;121(3):742-9. doi: 10.1016/0003-9861(67)90063-x.
5
Effect of phenobarbital on the activities of drug-metabolizing enzymes and electron transport system of liver microsomes in alloxan diabetes and thyroxine treated rats.苯巴比妥对四氧嘧啶糖尿病大鼠及甲状腺素处理大鼠肝脏微粒体药物代谢酶活性和电子传递系统的影响。
Jpn J Pharmacol. 1969 Mar;19(1):45-52. doi: 10.1254/jjp.19.45.
6
Effect of phenobarbital on the level of gossypol in the liver and the effect of gossypol and phenobarbital on liver microsomal O-demethylation and lipid peroxidation activities in the rat.苯巴比妥对大鼠肝脏中棉酚水平的影响以及棉酚和苯巴比妥对大鼠肝脏微粒体O-去甲基化和脂质过氧化活性的影响。
J Nutr. 1974 Dec;104(12):1567-75. doi: 10.1093/jn/104.12.1567.
7
Stimulation of hepatic protein synthesis in rats fed an adequate protein diet after a low protein diet.
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8
Studies on the induction of CO-binding pigments in liver microsomes by phenobarbital and 3-methylcholanthrene.苯巴比妥和3-甲基胆蒽对肝微粒体中一氧化碳结合色素诱导作用的研究。
Biochem Biophys Res Commun. 1967 Nov 30;29(4):521-6. doi: 10.1016/0006-291x(67)90515-3.
9
Influence of dietary thiamin on phenobarbital induction of rat hepatic enzymes responsible for metabolizing drugs and carcinogens.膳食硫胺素对苯巴比妥诱导大鼠肝脏中负责代谢药物和致癌物的酶的影响。
Drug Nutr Interact. 1983;2(2):117-30.
10
Magnetic and spectrophotometric properties of the microsomal carbon monoxide binding pigment.微粒体一氧化碳结合色素的磁性和分光光度特性
Arch Biochem Biophys. 1967 Apr;120(1):204-13. doi: 10.1016/0003-9861(67)90615-7.

引用本文的文献

1
The effect of phenytoin, phenobarbitone, dexamethasone and flurbiprofen on misonidazole neurotoxicity in mice.苯妥英、苯巴比妥、地塞米松和氟比洛芬对小鼠米索硝唑神经毒性的影响。
Br J Cancer. 1984 Feb;49(2):207-13. doi: 10.1038/bjc.1984.33.
2
The effect of phenobarbitone on the incorporation of delta-aminolaevulinic acid into rat liver microsomes.苯巴比妥对δ-氨基乙酰丙酸掺入大鼠肝脏微粒体的影响。
Biochem J. 1969 Aug;114(1):7P. doi: 10.1042/bj1140007pa.
3
Increased renal carcinogenesis by dimethyl nitrosamine in protein deficient rats.蛋白质缺乏的大鼠中，二甲基亚硝胺导致肾癌发生增加。
Br J Exp Pathol. 1970 Dec;51(6):587-90.
4
The effect of protein deficiency and microsomal enzyme induction by DDT and phenobarbitone on the acute toxicity of chloroform and a pyrrolizidine alkaloid, retrorsine.蛋白质缺乏以及滴滴涕和苯巴比妥对微粒体酶的诱导作用对氯仿和一种吡咯里西啶生物碱——倒千里光碱急性毒性的影响。
Br J Exp Pathol. 1970 Jun;51(3):317-21.
5
Instant cirrhosis. An improved method for producing cirrhosis of the liver in rats by simultaneous administration of carbon tetrachloride and phenobarbitone.速发性肝硬化。一种通过同时给予四氯化碳和苯巴比妥在大鼠中诱导肝硬化的改良方法。
Br J Exp Pathol. 1969 Oct;50(5):502-6.
6
The effect of cirrhosis of the liver on microsomal detoxications and cytochrome P-450.肝硬化对微粒体解毒作用及细胞色素P - 450的影响。
Br J Exp Pathol. 1969 Dec;50(6):578-83.
7
The effect of nutrition and hormonal status on cytochrome P-450 and its induction.营养与激素状态对细胞色素P - 450及其诱导作用的影响。
Biochem J. 1969 Dec;115(5):27P-28P. doi: 10.1042/bj1150027p.
8
A dietary factor required for the induction of hepatic microsomal cytochrome P-450 by phenobarbitone.苯巴比妥诱导肝微粒体细胞色素P - 450所需的膳食因素。
Biochem J. 1969 Oct;114(4):77P-78P. doi: 10.1042/bj1140077pb.
9
The effect of linoleic acid, peroxidation and antioxidants on induction of cytochrome P-450 in rat liver.亚油酸、过氧化作用及抗氧化剂对大鼠肝脏细胞色素P - 450诱导的影响。
Biochem J. 1971 Jul;123(4):28P. doi: 10.1042/bj1230028pa.
10
A requirement for dietary lipids for induction of cytochrome P-450 by phenobarbitone in rat liver microsomal fraction.大鼠肝微粒体部分中苯巴比妥诱导细胞色素P-450所需的膳食脂质。
Biochem J. 1971 May;122(4):569-73. doi: 10.1042/bj1220569.