Wegerhof P H, Lämmler G, Sänger I, Zahner H
Tropenmed Parasitol. 1979 Sep;30(3):376-82.
After oral administration of furazolidone in doses of 5 x 50 mg/kg and 1 x 100 mg/kg body weight to Litomosoides carinii--infected Mastomys natalensis microfilaraemia decreased continuously and was reduced by more than 98% 42 days after start of treatment. After the 5-day treatment all adult female and male worms were found dead and encapsulated within 2 weeks, whereas after the single dose 100% of the female parasites were encapsulated 28 days after treatment. In untreated animals quantiative examinations of the intrauterine stages showed an average number of 500 x 103 embryos per adult female worm. Following the 5-day treatment the number of embryos per female parasite was reduced after 42 days to 12.5 x 103, and after the single treatment to 26.9 x 103. By classification into 5 different stages (2- and 4-cell stages, Morula stage, "Horse-shoe" stage, "Ring" and "Brezel" stages, and intruterine microfilariae) an embryogram showed a continuous increase in pathologically-altered embryos during the whole observation period. The 2- and 4-cell stages suffered the most damaged. By 16 days after the end of the 5-day treatment and by 28 days after the single treatment all embryonic stages in the uteri were found to be pathologically altered. Furazolidone possessess high macrofilaricidal activity together with a considerable adverse effect on embryognesis and some delayed effect on microfilaraemia.
以5×50mg/kg和1×100mg/kg体重的剂量给感染卡氏丝虫的南非乳鼠口服呋喃唑酮后，微丝蚴血症持续下降，治疗开始42天后降低了98%以上。5天治疗后，所有成年雌虫和雄虫均死亡并在2周内被包囊化，而单次给药后，100%的雌虫在治疗后28天被包囊化。在未治疗的动物中，对子宫内各阶段的定量检查显示，每条成年雌虫平均有500×10³个胚胎。5天治疗后，42天后每条雌虫的胚胎数减少到12.5×10³，单次治疗后减少到26.9×10³。通过分为5个不同阶段（2细胞和4细胞阶段、桑椹胚阶段、“马蹄”阶段、“环”和“椒盐卷饼”阶段以及子宫内微丝蚴）绘制胚胎图显示，在整个观察期内，病理改变的胚胎持续增加。2细胞和4细胞阶段受损最严重。5天治疗结束后16天以及单次治疗后28天，子宫内所有胚胎阶段均出现病理改变。呋喃唑酮具有很高的杀成虫活性，同时对胚胎发生有相当大的不良影响，对微丝蚴血症有一些延迟作用。
