Lämmler G, Sänger I, Wegerhof P H
Tropenmed Parasitol. 1978 Jun;29(2):178-82.
Investigations were carried out on the filaricidal activity of furazolidone against Litomosoides carinii infection in Mastomys natalensis. Oral administration of the drug in daily doses of 25, 50, 75, and 150 mg/kg body weight on 5 consecutive days revealed respectively 96,4, 99,3 and, with the two later doses, 100% reduction of macrofilariae in the pleural cavities, and produced a continuing dose-dependant decrease of microfilaraemia in the circulating blood. After oral doses of 5 x 50 mg/kg, all the adult parasites were killed within two weeks of the start of treatment and were found encapsulated in fibrinous masses in the pleural cavities. Deformed and degenerated embryonic stages could be seen in female worms as early as 3 days after the end of treatment. Furazolidone possesses a considerable chemotherapeutic index.
对呋喃唑酮针对豚鼠体内卡里尼丝虫感染的杀丝虫活性进行了研究。连续5天每天按25、50、75和150毫克/千克体重的剂量口服该药，结果显示胸腔内的大丝虫分别减少了96.4%、99.3%，后两个剂量组的大丝虫减少了100%，并且使循环血液中的微丝蚴血症持续呈剂量依赖性下降。口服5×50毫克/千克剂量后，所有成虫在治疗开始后的两周内被杀死，并被发现包裹在胸腔内的纤维蛋白块中。在治疗结束后仅3天，就可以在雌虫体内看到变形和退化的胚胎阶段。呋喃唑酮具有相当高的化疗指数。
