Crockford P M, Salmon P A
Can Med Assoc J. 1970 Jul 18;103(2):147-50.
Ten obese patients were subjected to insulin tolerance tests (0.2 unit per kg. regular insulin intravenously) and/or treadmill exercise tolerance testing (2.6 m.p.h. at 11 degrees angulation) before and after surgically induced weight reduction. Immunoreactive growth hormone (IRGH) responses returned to normal with weight reduction in all but one-a grossly obese woman studied relatively early in the postoperative period when still far from the ideal body weight. Five of these patients and two additional subjects had intravenous glucose tolerance tests (0.5 g. per kg.) before and after weight reduction. In all, there was a significant diminution in immunoreactive insulin (IRI) values, accompained by little or no change in the glucose disappearance rate (K(G)) and a significant improvement in insulin effectiveness as indicated by the calculated "insulinogenic index". It was concluded that the abnormalities in IRGH and IRI secretion, as well as the insulin resistance in obesity, are probably secondary and not of primary importance in the etiology of this disorder.
对10名肥胖患者在手术诱导体重减轻前后进行了胰岛素耐量试验（每公斤体重静脉注射0.2单位正规胰岛素）和/或跑步机运动耐量试验（速度为每小时2.6英里，倾斜度为11度）。除一名严重肥胖女性外，所有患者的免疫反应性生长激素（IRGH）反应随着体重减轻恢复正常，该女性在术后早期进行研究，当时仍远未达到理想体重。其中5名患者和另外2名受试者在体重减轻前后进行了静脉葡萄糖耐量试验（每公斤体重0.5克）。总体而言，免疫反应性胰岛素（IRI）值显著降低，同时葡萄糖消失率（K(G)）几乎没有变化或没有变化，并且计算得出的“胰岛素生成指数”表明胰岛素有效性显著提高。得出的结论是，IRGH和IRI分泌异常以及肥胖中的胰岛素抵抗可能是继发性的，在该疾病的病因中并非首要重要因素。
