Gürtler R, Raderecht C
Folia Haematol Int Mag Klin Morphol Blutforsch. 1975;102(6):619-24.
Problems of maintaining therapy for acute myelocytic leukemias in adults are discussed. The analysis of the maintaining therapy in 22 patients affected with an acute myelocytic leukemia and living for more than 6 months revealed that the interval therapy with a high dosage of cytostatic combinations in the sense of the COAP scheme is preferable compared with the daily administration of 6-mercaptopurin, in addition methotrexate twice a week. Reasons for this are discussed.
讨论了成人急性髓细胞白血病维持治疗的问题。对22例患有急性髓细胞白血病且存活超过6个月的患者的维持治疗分析表明，与每日服用6-巯基嘌呤及每周两次甲氨蝶呤相比，按照COAP方案采用高剂量细胞抑制联合用药的间歇疗法更为可取。文中讨论了其原因。
