序贯联合化疗用于成人急性髓性白血病的诱导和维持治疗（作者译）
[Induction and maintenance treatment of acute myelogenous leukemia in adults by sequential use of combination chemotherapy (author's transl)].
作者信息
Fülle H H
出版信息
Med Klin. 1977 Apr 15;72(15):642-9.
The therapeutic regimens for acute myelogenous leukemia in 2 different periods of time will be described with comparison of their results. A. 28 adults were treated with cytosine arabinoside and 6-thioguanine only. Thereby, 28% complete and 16% partial remissions were achieved. The mean duration of the complete remissions was 23 weeks. The mean survival time of the patients with complete remission amounted to 53 weeks B. 46% complete and 12% partial remissions were obtained in 37 patients treated with cytosine arabinoside and 6-thioguanine doubling the dosage of the above mentioned regimen followed by 3 cycles of TRAP (and COAP). Using a maintenance therapy with modified TRAP, COAP, and POMP cycles the complete remissions lasted 47 weeks at an average. The mean survival time of patients with complete remission was 87 weeks after start of treatment.
将描述急性髓性白血病在两个不同时期的治疗方案，并比较其结果。A. 仅用阿糖胞苷和6-硫鸟嘌呤治疗28名成人。由此，完全缓解率为28%，部分缓解率为16%。完全缓解的平均持续时间为23周。完全缓解患者的平均生存时间为53周。B. 37名患者接受阿糖胞苷和6-硫鸟嘌呤治疗，将上述方案的剂量加倍，随后进行3个周期的TRAP（和COAP），完全缓解率为46%，部分缓解率为12%。采用改良的TRAP、COAP和POMP周期进行维持治疗，完全缓解平均持续47周。治疗开始后，完全缓解患者的平均生存时间为87周。
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