Nauth H F, Hort W, Hubinger R
Z Kardiol. 1979 Dec;68(12):832-8.
In the hearts of 100 unselected adult autopsies (average age 65 years) the coronary arteries and their major branches were investigated. After opening the lumen, the vessels were measured, and the location of all sclerotic lesions was identified, including fatty streaks. The frequency of distribution of advanced sclerotic changes was similar to that of lipid and fibrolipid plaques. 1003 major coronary artery branches were studied. 25% of them showed sclerotic changes in contrast to 92% in the coronary arteries themselves. There was a good correlation between the sclerotic lesions in the coronary arteries and their branches: no changes were found in the branches the corresponding stems of which were unchanged. In contrast to that, sclerotic branches nearly always originated from sclerotic areas of the coronary arteries. Branches of the left anterior descending artery were more frequently affected by atherosclerosis (39%) than branches of the right coronary artery (17%). Contrary to the right coronary artery sclerotic changes of the proximal branches of the left anterior descending and the left circumflex artery were significantly more frequent than sclerotic lesions of the distal branches. The frequency of sclerotic lesions in the branches was similar to that in the coronary arteries; the proximal part was more frequently affected than the distal one. In addition, the peripheral decreasing frequency of sclerotic changes, which was found to be more pronounced in the left coronary arteries than in the right one, showed a similar behaviour in the corresponding branches. Our investigations indicate the vessel's diameter to be a significant (but not the only) factor in atherosclerosis development in coronary arteries and their branches. In case of a corresponding size of lumen, the frequency of sclerotic changes in the coronary arteries was approximately the same as in their branches.
在100例未经挑选的成人尸体解剖（平均年龄65岁）中，对冠状动脉及其主要分支进行了研究。打开管腔后，测量血管，并确定所有硬化病变的位置，包括脂肪条纹。晚期硬化改变的分布频率与脂质和纤维脂质斑块相似。研究了1003条主要冠状动脉分支。其中25%出现硬化改变，而冠状动脉本身为92%。冠状动脉及其分支中的硬化病变之间存在良好的相关性：相应主干未发生改变的分支未发现变化。相反，硬化分支几乎总是起源于冠状动脉的硬化区域。左前降支的分支比右冠状动脉的分支更常受到动脉粥样硬化的影响（39%对17%）。与右冠状动脉相反，左前降支和左旋支近端分支的硬化改变明显比远端分支的硬化病变更频繁。分支中硬化病变的频率与冠状动脉相似；近端比远端更常受到影响。此外，硬化改变外周频率降低，在左冠状动脉中比右冠状动脉更明显，在相应分支中也表现出类似的情况。我们的研究表明，血管直径是冠状动脉及其分支动脉粥样硬化发展的一个重要（但不是唯一）因素。在管腔大小相应的情况下，冠状动脉中硬化改变的频率与其分支大致相同。
