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4-Threonine-oxytocin: a more active and specific oxytocic agent than oxytocin.

作者信息

Manning M, Sawyer W H

出版信息

Nature. 1970 Aug 15;227(5259):715-6. doi: 10.1038/227715a0.

DOI:10.1038/227715a0
PMID:5432071
Abstract
摘要

相似文献

1
4-Threonine-oxytocin: a more active and specific oxytocic agent than oxytocin.
Nature. 1970 Aug 15;227(5259):715-6. doi: 10.1038/227715a0.
2
Synthesis and some pharmacological properties of [4-threonine,7-sarcosine]oxytocin, a peptide with high oxytocic potency, and of [4-threonine,7-N-methylalanine]oxytocin.
J Med Chem. 1983 Dec;26(12):1786-7. doi: 10.1021/jm00366a028.
3
Combined high oxytocic with negligible antidiuretic and pressor activities in multisubstituted oxytocins.在多取代催产素中,结合了高催产活性以及可忽略不计的抗利尿和升压活性。
J Med Chem. 1977 Apr;20(4):492-5. doi: 10.1021/jm00214a006.
4
Glutamine isomers of oxytocin and deamino-oxytocin: synthesis and pharmacological properties of [4-N4-methyl-L-asparagine]-oxytocin and [1-beta-mercaptopropionic acid, 4-N4-methyl-L-asparagine]-oxytocin.催产素和去氨基催产素的谷氨酰胺异构体:[4-N4-甲基-L-天冬酰胺]-催产素和[1-β-巯基丙酸,4-N4-甲基-L-天冬酰胺]-催产素的合成及药理特性
Mol Pharmacol. 1969 Jan;5(1):83-9.
5
Synthesis and some pharmacological properties of [1-(L-2-hydroxy-3-mercaptopropanoic acid), 4-threonine]oxytocin (hydroxy [4-thr]oxytocin), a peptide with strikingly high oxytocic potency and of [1-(L-2-hydroxy-3-mercaptopropanoic acid)]oxytocin (hydroxy-oxytocin).
J Med Chem. 1976 Mar;19(3):376-80. doi: 10.1021/jm00225a007.
6
A fraction resembling oxytocin from Squalus acanthias: pharmacological comparisons with synthetic peptides.一种来自棘鲛的类似催产素的成分:与合成肽的药理学比较。
Gen Comp Endocrinol. 1970 Aug;15(1):52-8. doi: 10.1016/0016-6480(70)90096-1.
7
Solid-phase synthesis of (4-threonine)-oxytocin. A more potent and specific oxytocic agent than oxytocin.(4-苏氨酸)-催产素的固相合成。一种比催产素更有效且更具特异性的催产剂。
Biochemistry. 1970 Sep 29;9(20):3925-30. doi: 10.1021/bi00822a010.
8
(2,4-Dileucine)exytocin. A polypeptide with natrituretic and diuretic activities, and an inhibitor of the oxytocic response of oxytocin.(2,4-二亮氨酸)催产素。一种具有利钠和利尿活性的多肽,也是催产素催产反应的抑制剂。
J Med Chem. 1971 Nov;14(11):1050-1. doi: 10.1021/jm00293a007.
9
Failure of 1-L-penicillamine-oxytocin and 1-deaminopenicillamine-oxytocin to inhibit the uterine effect of oxytocin in rabbits in vivo.
Endocrinology. 1970 Jan;86(1):71-6. doi: 10.1210/endo-86-1-71.
10
Some pharmacological actions of four synthetic analogues of oxytocin.催产素四种合成类似物的一些药理作用。
Br J Pharmacol Chemother. 1957 Jun;12(2):209-14. doi: 10.1111/j.1476-5381.1957.tb00121.x.

引用本文的文献

1
Revisiting oxytocin through the medium of isonitriles.重新审视异腈媒介下的催产素。
J Am Chem Soc. 2012 Aug 15;134(32):13244-7. doi: 10.1021/ja3063452. Epub 2012 Aug 2.
2
The deamino derivatives of (4-threonine)-oxytocin and (4-threonine)-mesotocin; analogs possessing a surprising spectrum of diminished pharmacological activities.(4-苏氨酸)-催产素和(4-苏氨酸)-中催产素的脱氨基衍生物;具有一系列令人惊讶的药理学活性降低的类似物。
Experientia. 1971;27(11):1372-4. doi: 10.1007/BF02136746.