（2,4-二亮氨酸）催产素。一种具有利钠和利尿活性的多肽，也是催产素催产反应的抑制剂。 - Suppr | 超能文献

(2,4-Dileucine)exytocin. A polypeptide with natrituretic and diuretic activities, and an inhibitor of the oxytocic response of oxytocin.

作者信息

Hruby V J, Chan W Y

出版信息

J Med Chem. 1971 Nov;14(11):1050-1. doi: 10.1021/jm00293a007.

DOI:10.1021/jm00293a007

Abstract

摘要

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1

(2,4-Dileucine)exytocin. A polypeptide with natrituretic and diuretic activities, and an inhibitor of the oxytocic response of oxytocin.（2,4-二亮氨酸）催产素。一种具有利钠和利尿活性的多肽，也是催产素催产反应的抑制剂。

J Med Chem. 1971 Nov;14(11):1050-1. doi: 10.1021/jm00293a007.

2

Solid phase synthesis of (3,4-dileucine)-oxytocin and a study of some of its pharmacological properties.（3,4-二亮氨酸）-催产素的固相合成及其部分药理性质研究

J Med Chem. 1972 Jan;15(1):11-2. doi: 10.1021/jm00271a004.

3

An investigation of the natriuretic, antidiuretic and oxytocic actions of neurohypophysial hormones and related peptides: delineation of separate mechanisms of action and assessment of molecular requirements.

J Pharmacol Exp Ther. 1976 Mar;196(3):746-57.

4

Synthesis and some pharmacological properties of [4-threonine,7-sarcosine]oxytocin, a peptide with high oxytocic potency, and of [4-threonine,7-N-methylalanine]oxytocin.

J Med Chem. 1983 Dec;26(12):1786-7. doi: 10.1021/jm00366a028.

5

Combined high oxytocic with negligible antidiuretic and pressor activities in multisubstituted oxytocins.在多取代催产素中，结合了高催产活性以及可忽略不计的抗利尿和升压活性。

J Med Chem. 1977 Apr;20(4):492-5. doi: 10.1021/jm00214a006.

6

4-Leucine-oxytocin: natriuretic, diuretic, and antivasopressin polypeptide.4-亮氨酸-催产素：利钠、利尿及抗血管升压素多肽。

Science. 1968 Jul 19;161(3838):280-1. doi: 10.1126/science.161.3838.280.

7

Natriuretic, diuretic and anti-arginine-vasopressin (ADH) effects of two analogs of oxytocin: [4-leucine]-oxytocin and [2,4-diisoleucine]-oxytocin.两种催产素类似物：[4-亮氨酸]-催产素和[2,4-二异亮氨酸]-催产素的利钠、利尿及抗精氨酸加压素（ADH）作用

J Pharmacol Exp Ther. 1970 Sep;174(3):541-9.

8

4-Threonine-oxytocin: a more active and specific oxytocic agent than oxytocin.

Nature. 1970 Aug 15;227(5259):715-6. doi: 10.1038/227715a0.

9

(1-beta-mercapto-beta,beta-diethylpropionic acid,4-leucine)-8-lysine-vasopressin and (1-beta-mercapto-beta,beta-diethylpropionic acid,4-leucine)oxytocin, compounds possessing antihormonal properties.（1-β-巯基-β，β-二乙基丙酸，4-亮氨酸）-8-赖氨酸-加压素和（1-β-巯基-β，β-二乙基丙酸，4-亮氨酸）催产素，具有抗激素特性的化合物。

J Med Chem. 1974 Sep;17(9):969-72. doi: 10.1021/jm00255a012.

10

Synthesis and some pharmacological properties of [1-(L-2-hydroxy-3-mercaptopropanoic acid), 4-threonine]oxytocin (hydroxy [4-thr]oxytocin), a peptide with strikingly high oxytocic potency and of [1-(L-2-hydroxy-3-mercaptopropanoic acid)]oxytocin (hydroxy-oxytocin).

J Med Chem. 1976 Mar;19(3):376-80. doi: 10.1021/jm00225a007.

引用本文的文献

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Competitive inhibitors of neurohypophyseal hormones on adenylate cyclase from the toad urinary bladder.神经垂体激素对蟾蜍膀胱腺苷酸环化酶的竞争性抑制剂。

Experientia. 1972 Aug 15;28(8):959-60. doi: 10.1007/BF01924972.

2

Some pharmacological properties of (4-leucine)-arginine-vasotocin.（4-亮氨酸）-精氨酸-血管加压素的一些药理学特性。

Experientia. 1973 Feb 15;29(2):171-3. doi: 10.1007/BF01945456.

3

Synthesis of (4-leucine)-arginine-vasotocin, a natriuretic analogue of arginine-vasotocin.

Experientia. 1973 Feb 15;29(2):170-1. doi: 10.1007/BF01945455.