醛固酮的胎盘转运与胎儿分泌
Transplacental passage and fetal secretion of aldosterone.
作者信息
Bayard F, Ances I G, Tapper A J, Weldon V V, Kowarski A, Migeon C J
出版信息
J Clin Invest. 1970 Jul;49(7):1389-93. doi: 10.1172/JCI106356.
Abstract
The transplacental passage and the production of aldosterone were studied in late pregnancy during a constant infusion of 1,2-aldosterone-(3)H to mothers at the time of elective cesarean section. It was found that, while maternal aldosterone crossed the placenta, there was a significant secretion of aldosterone by the fetus. The aldosterone concentration in fetal plasma was 2-12 times higher than that of the corresponding mothers. Pregnancy had no effect on the metabolic clearance rate of aldosterone, but it increased the rate of production of this steroid. However, the increments that we observed were smaller than those reported in previous reports. The discrepancy was probably due to differences in body posture, our subjects being supine for at least 10 hr at the time of study.
摘要
在择期剖宫产时，对处于妊娠晚期的母亲持续输注1,2-醛固酮-（3）H，研究其经胎盘转运及醛固酮的产生情况。结果发现，虽然母体醛固酮可穿过胎盘，但胎儿也会大量分泌醛固酮。胎儿血浆中的醛固酮浓度比相应母亲的高2至12倍。妊娠对醛固酮的代谢清除率没有影响，但会增加这种类固醇的产生率。然而，我们观察到的增加幅度小于先前报告中的幅度。这种差异可能是由于身体姿势的不同，我们的研究对象在研究时至少仰卧了10小时。
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