Markovska V, Georgiev V, Ankov V
Acta Physiol Pharmacol Bulg. 1979;5(4):27-34.
The influence of X-ray irradiation on the dopamine level in brain and in corpus striatum of male albino rats is studied. The changes in the influence of the dopaminergic agonists apomorphine and L-DOPA, applied independently and in combination, on the dopamine level in brain and striatum, are established comparatively (in non-irradiated rats and in rats on the 72nd hour after irradiation with 900 R). Apomorphine is found to have no significant influence on the dopamine level in brain and striatum of non-irradiated rats, while L-DOPA and its combination with apomorphine raise this level. On the 72nd hour after irradiation with 900 R there is no essential change in the dopamine level in brain and the striatum; apomorphine raises the dopamine level in brain and striatum; the effect of L-DOPA and its combination with apomorphine is potentiated with respect to the increase of the dopamine level in brain and striatum.
研究了X射线照射对白化雄性大鼠脑和纹状体中多巴胺水平的影响。比较了多巴胺能激动剂阿扑吗啡和左旋多巴单独及联合应用时，对非照射大鼠以及照射900伦琴后72小时大鼠脑和纹状体中多巴胺水平影响的变化。结果发现，阿扑吗啡对非照射大鼠脑和纹状体中的多巴胺水平无显著影响，而左旋多巴及其与阿扑吗啡联合应用可提高该水平。照射900伦琴后72小时，脑和纹状体中的多巴胺水平无本质变化；阿扑吗啡可提高脑和纹状体中的多巴胺水平；左旋多巴及其与阿扑吗啡联合应用对脑和纹状体中多巴胺水平升高的作用增强。
