α-对氯苯氧异丁酸对大鼠类异戊二烯化合物代谢的影响。
Effect of alpha-p-chlorophenoxyisobutyrate on the metabolism of isoprenoid compounds in the rat.
作者信息
Krishnaiah K V, Ramasarma T
出版信息
Biochem J. 1970 Feb;116(3):321-7. doi: 10.1042/bj1160321.
Abstract
- Feeding of alpha-p-chlorophenoxyisobutyrate (CPIB) to rats increased ubiquinone concentration in the liver but not in other tissues. The increase was progressive with the time of feeding and related to the concentration of CPIB in the diet. 2. Incorporation of [1-(14)C]acetate, but not of [2-(14)C]mevalonate, into sterols in the liver in vivo or by liver slices in vitro was decreased on feeding the rats with CPIB. However, incorporation of mevalonate into ubiquinone increased. 3. CPIB, when added in low concentrations to liver slices, had no effect on isoprene synthesis from acetate; higher concentrations, however, were inhibitory. 4. No activation of ubiquinone synthesis from mevalonate was observed when CPIB was added to the liver slices synthesizing ubiquinone. 5. The increase in ubiquinone in CPIB-fed animals appears to be due to increased synthesis in the initial stages and to decreased catabolism in the later stages. 6. An inverse relationship was found between the concentration of ubiquinone in the liver and the serum sterol concentration in CPIB-fed rats.
摘要
- 给大鼠喂食α - 对氯苯氧异丁酸（CPIB）会增加肝脏中泛醌的浓度，但其他组织中则不会。这种增加随着喂食时间而逐渐增加，并且与饮食中CPIB的浓度有关。2. 给大鼠喂食CPIB后，体内肝脏或体外肝切片中[1 - （14）C]乙酸盐而非[2 - （14）C]甲羟戊酸掺入固醇的量减少。然而，甲羟戊酸掺入泛醌的量增加。3. 当低浓度的CPIB添加到肝切片中时，对乙酸盐合成异戊二烯没有影响；然而，较高浓度则具有抑制作用。4. 当将CPIB添加到合成泛醌的肝切片中时，未观察到由甲羟戊酸合成泛醌的激活。5. 喂食CPIB的动物中泛醌的增加似乎是由于初始阶段合成增加以及后期分解代谢减少。6. 在喂食CPIB的大鼠中，发现肝脏中泛醌的浓度与血清固醇浓度之间存在负相关关系。
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Biochem J. 1970 Feb;116(3):321-7. doi: 10.1042/bj1160321.
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Biosynthesis of ubiquinone and ubichromenol in vitamin A-deficient rats.
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